IP Library › Granted Patent US 10,301,283
Granted Patent B2
US 10,301,283 · App. 15/886,526 · Granted May 28, 2019

2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation

Inventors: William J. Hoekstra (Durham, NC); Nakyen Choy (Carmel, IN); Carl DeAmicis (Indianapolis, IN); Daniel Knueppel (Zionsville, IN); Jim Renga (Spokane, WA); Michael T. Sullenberger (Westfield, IN); Gregory Whiteker (Carmel, IN); Yuanming Zhu (Carmel, IN); Gary D. Gustafson (Zionsville, IN)
Assignee: Dow Agrosciences, LLC
C07D401/14C07D213/50C07D213/65C07D401/06C07D401/12
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,301,283
App. No.
15/886,526
Granted
May 28, 2019
Kind
B2
Abstract

Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and 1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-substituted-pyridin-2-yl)ethanones and processes for their preparation.

Claims (20)

1. A compound of Formula VII, or salt thereof:

wherein

R 1 is

or

Br;

R 2 is

ethoxy;

2,4-difluorophenyl;

—N(OCH 3 )(CH 3 );

—N(CH 3 )(CH 3 );

—N(CH 2 CH 3 )(CH 2 CH 3 ); or

R 3 and R 4 are taken together to form a carbonyl;

with the proviso that when R 2 is 2,4-difluorophenyl or ethoxy and R 3 and R 4 are taken together to form a carbonyl, then R 1 is not Br.

2. A compound of Formula VIII, or salt thereof:

wherein

R 1 is

3. The compound of claim 1 , or salt thereof, wherein R 1 is Br.

4. The compound of claim 1 , or salt thereof, wherein R 2 is

5. The compound of claim 1 , or salt thereof, wherein R 1 is Br and R 2 is

6. The compound of claim 1 , or salt thereof, wherein the compound of Formula VII is of the formula:

Assignments (7)
CHANGE OF NAME Recorded Nov 8, 2021
From: DOW AGROSCIENCES LLC
To: CORTEVA AGRISCIENCE LLC
Reel/Frame 058044/0184 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2019
From: VPS-3, INC.
To: DOW AGROSCIENCES LLC
Reel/Frame 048842/0184 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2019
From: VIAMET PHARMACEUTICALS (NC), INC.
To: VPS-3, INC.
Reel/Frame 048612/0945 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2019
From: HOEKSTRA, WILLIAM J.
To: VIAMET PHARMACEUTICALS, INC.
Reel/Frame 048612/0633 →
CHANGE OF NAME Recorded Mar 15, 2019
From: VIAMET PHARMACEUTICALS, INC.
To: VIAMET PHARMACEUTICALS (NC), INC.
Reel/Frame 048615/0368 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2019
From: DOW AGROSCIENCES LLC
To: VIAMET PHARMACEUTICALS, INC.
Reel/Frame 048613/0026 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2019
From: CHOY, NAKYEN; DEAMICIS, CARL; KNUEPPEL, DANIEL; RENGA, JAMES M.; SULLENBERGER, MICHAEL T.; WHITEKER, GREGORY T.; ZHU, YUANMING; GUSTAFSON, GARY D.
To: DOW AGROSCIENCES LLC
Reel/Frame 048612/0768 →
Continuity (3)
Division 15126353
Provisional Application 61955680 · Mar 19, 2014
Related Publication 20180155324A1 · Jun 7, 2018