Pain management using cryogenic remodeling
Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.
1. A method for treating pain associated with a nerve of a patient, the nerve underlying a skin surface, the method comprising:
inserting a distal end of a needle through the skin surface and into a target tissue, wherein the needle has a lumen extending distally toward the distal end, and wherein a cooling fluid supply tube extends distally within the lumen of the needle;
stimulating and measuring the nerve via an electro-myographic system coupled to an electrically conductive surface of the needle to identify or verify a location of the nerve;
transmitting cooling fluid from a cooling fluid source to the needle such that the cooling fluid flows through the cooling fluid supply tube and vaporizes to cool the needle; and
cooling the target tissue with the needle to a temperature between about 10° C. to about −5° C. such that the nerve is temporarily stunned to inhibit short term pain signals along the nerve, wherein the temperature does not induce significant apoptosis or necrosis such that the nerve is capable of transmitting signals after the target tissue warms.
2. The method of claim 1 , wherein the target tissue is cooled to a temperature greater than or equal to 0° C. such that the nerve is temporarily stunned.
3. The method of claim 1 , wherein the target tissue is cooled to a temperature from 0° C. to −5° C. such that the nerve is temporarily stunned.
4. The method of claim 1 , wherein the target tissue is cooled during a 20 second treatment cycle.
5. The method of claim 1 , wherein the nerve is temporarily stunned to inhibit pain from a headache.
6. The method of claim 1 , wherein the nerve is temporarily stunned to inhibit back pain.
7. The method of claim 1 , further comprising controlling a pressure of the vaporizing cooling fluid flow within the needle with a pressure relief valve such that a temperature of the target tissue is within a desired treatment temperature range.
8. The method of claim 1 , wherein the needle is partially surrounded by an electrical insulator, and wherein the distal end of the needle comprises the electrically conductive surface configured to be able to conduct electrical energy from the electro-myographic system.
9. The method of claim 1 , wherein the nerve is temporarily stunned to inhibit acute pain occurring from post-surgical pain associated with thoracotomy or inguinal hernia repair.
10. The method of claim 1 , wherein the nerve is temporarily stunned to inhibit acute pain occurring from pregnancy labor or delivery.
11. A system for treating pain or spasm associated with a nerve of a patient, the nerve underlying a skin surface, the system comprising:
a needle having a distal end, a lumen extending distally toward the distal end, wherein the distal end of the needle is configured to be inserted through the skin surface and into a target tissue;
an electro-myographic system coupleable to an electrically conductive surface of the needle, wherein the electrically conductive surface is configured to conduct electrical energy from the electro-myographic system to stimulate and measure the nerve so as to identify or verify a location of the nerve;
a cooling fluid supply tube extending distally within the lumen of the needle such that the cooling fluid supply tube extends distally of the skin surface when the needle is inserted into the target tissue, the cooling fluid supply tube coupleable with a cooling fluid source such that cooling fluid flows from the cooling fluid source through the cooling fluid supply tube distally of the skin surface and vaporizes to cool the needle such that the needle cools the target tissue to a temperature between about 10° C. to about −5° C. such that the nerve is temporarily stunned to inhibit short term pain signals or spasm along the nerve, wherein the temperature does not induce significant apoptosis or necrosis such that the nerve is capable of transmitting signals after the target tissue warms;
a pressure relief valve configured to control a pressure of the vaporizing cooling fluid flow within the needle such that a temperature of the target tissue is within a desired treatment temperature range; and
a handpiece having a handle and supporting the needle.
12. The system of claim 11 , wherein the pressure relief valve is integrated with the handpiece supporting the needle.
13. The system of claim 11 , wherein the pressure relief valve comprises a biasing spring mechanically urging a valve member against a valve seat to maintain an adjustable pressure within the needle within a desired pressure range.
14. The system of claim 13 , wherein the biasing spring of the pressure relief valve is disposed outside the valve seat.
15. The system of claim 14 , wherein the pressure relief valve is disposed adjacent an interface between the needle and the handpiece.
16. The system of claim 11 , wherein the needle is releasably coupleable to the handpiece.
17. The system of claim 16 , wherein the system further comprises a detent engaged by a spring supported catch to releasably couple the needle to the handpiece.
18. The system of claim 11 , wherein the pressure relief valve is configured to maintain a pressure within a lumen of the needle within a desired pressure range.
19. The system of claim 11 , wherein the pressure is maintained such that the temperature of the target tissue is within a temperature range sufficient to only stun the nerve.
20. The system of claim 11 , wherein the needle is at least partially surrounded by an electrical insulator, and wherein the distal end of the needle comprises the electrically conductive surface.
21. The system of claim 20 , wherein the electrical insulator comprises a lubricious coating.
22. The system of claim 21 , wherein the lubricous coating has a thickness less than a thickness of the needle, such that thermal insulation provided by the lubricous coating is limited.
23. The system of claim 21 , wherein the lubricous coating is made from material having thermal conductivity which is less than that thermal conductivity of the needle.
24. The system of claim 11 , wherein the electro-myographic system is coupled to the electrically conductive surface of the needle via a coupler, wherein the coupler is accessible when the needle is inserted through the skin surface and into a target nerve.