IP Library Granted Patent US 11,154,076
Granted Patent B2
US 11,154,076 · App. 15/889,842 · Granted Oct 26, 2021

Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof

Inventors: Kirk E. Apt (Ellicott City, MD); Paul Warren Behrens (Ellicott City, MD); Jon Milton Hansen (Chandler, AZ); Joseph W. Pfeifer, III (Westminster, MD); Tracey Lynn Stahl (Pasadena, MD); Ross Zirkle (Mt. Airy, MD)
Assignee: DSM IP Assets B.V.
A23K20/158A23C9/1528A23D9/00A23D9/007A23K10/12A23K50/00A23K50/40A23K50/80A23L2/52A23L33/115A23L33/40A61K8/361A61K31/201A61K31/202A61K35/68A61Q19/00C11B1/10C11B3/04C12N1/105C12N1/125C12P7/6427C12P7/6472A23V2002/00A61K2800/10C12R2001/89C12R2001/90Y02A40/818
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Quick Facts
Patent No.
US 11,154,076
App. No.
15/889,842
Granted
Oct 26, 2021
Kind
B2
Abstract

The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.

Claims (6)

1. A blended oil composition comprising a vegetable oil and a microbial oil comprising a polyunsaturated fatty acids (PUFA) fraction produced from a single isolated strain of thraustochytrid microorganism, wherein said PUFA fraction comprises a triacylglycerol fraction which is at least 10% by weight of said PUFA fraction, wherein at least 12% by weight of the fatty acids in the triacylglycerol fraction is eicosapentaenoic acid (EPA), wherein at least 25% by weight of the fatty acids in the triacylglycerol fraction is docosahexaenoic acid (DHA), and wherein less than 5% by weight of the fatty acids in the triacylglycerol fraction is arachidonic acid (ARA), wherein said thraustochytrid microorganism is of the genus Schizochytrium or Thraustochytrium , and wherein said refined oil further comprises an effective amount of at least one added antioxidant to provide oxidative stability.

2. The vegetable oil of claim 1 , wherein the triacylglycerol fraction is at least 40% by weight of said PUFA fraction.

3. The vegetable oil of claim 1 , wherein at least 15% by weight of the fatty acids in the triacylglycerol fraction is eicosapentaenoic acid.

4. The vegetable oil of claim 1 , wherein at least 35% by weight of the fatty acids in the triacylglycerol fraction is docosahexaenoic acid.

5. The vegetable oil of claim 1 , wherein 2% or less by weight of the fatty acids in the triacylglycerol fraction is arachidonic acid.

6. The vegetable oil of claim 1 , wherein the fatty acids comprise less than about 5% by weight each of oleic acid, linoleicacid, linolenic acid, eicosenoic acid, and erucic acid.

Assignments (4)
CHANGE OF ASSIGNEE ADDRESS Recorded Sep 12, 2025
From: DSM IP ASSETS B.V.
To: DSM IP ASSETS B.V.
Reel/Frame 072873/0389 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 7, 2018
From: MARTEK BIOSCIENCES CORPORATION
To: DSM IP ASSETS B.V.
Reel/Frame 046661/0304 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2018
From: APT, KIRK E.; BEHRENS, PAUL WARREN; HANSEN, JON MILTON; PFEIFER, JOSEPH W., III; STAHL, TRACEY LYNN; ZIRKLE, ROSS
To: MARTEK BIOSCIENCES CORPORATION
Reel/Frame 045476/0470 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2018
From: MARTEK BIOSCIENCES CORPORATION
To: DSM IP ASSETS B.V.
Reel/Frame 045862/0573 →
Continuity (3)
Division 12729013 · Mar 22, 2010
Provisional Application 61296456 · Jan 19, 2010
Related Publication 20180295860A1 · Oct 18, 2018