IP Library › Patent Application 15892661
Patent Application
App. No. 15/892,661

METHODS AND COMPOSITIONS FOR INHIBITING CD32B EXPRESSING CELLS

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Quick Facts
Patent No.
US None
App. No.
15/892,661
Abstract

The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.

Claims (10)

1 . (canceled)

2 . (canceled)

3 . A nucleic acid encoding an Fc variant comprising at least amino acid modifications G236N and S267E as compared to a parent Fc polypeptide, wherein numbering is according to the EU index according to Kabat.

4 . An expression vector comprising the nucleic acid of claim 3 .

5 . A host cell comprising the vector of claim 4 .

6 . A method of treating an autoimmune disease comprising administering a protein comprising an Fc variant comprising at least amino acid modifications G236N and S267E as compared to a parent Fc polypeptide, wherein numbering is according to the EU index according to Kabat.

7 . (canceled)

8 . A nucleic acid encoding a heavy chain of an antibody, the heavy chain comprising an Fc variant comprising at least amino acid modifications G236N and S267E as compared to a parent Fc polypeptide, wherein numbering is according to the EU index according to Kabat.

9 . An expression vector comprising the nucleic acid of claim 8 .

10 . A host cell comprising the vector of claim 9 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 15, 2019
From: CHU, SEUNG YUP; DESJARLAIS, JOHN R.; KARKI, SHER BAHADUR; LAZAR, GREGORY ALAN; MOORE, GREGORY L.; VOSTIAR, IGOR
To: XENCOR, INC.
Reel/Frame 049756/0164 →