IP Library › Patent Application 15894442
Patent Application
App. No. 15/894,442

ANTIBODIES THAT BIND HUMAN PROTEIN TYROSINE PHOSPHATASE beta (HPTPbeta) AND USES THEREOF

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Quick Facts
Patent No.
US None
App. No.
15/894,442
Abstract

Antibodies and antigen binding fragments thereof that bind to human protein tyrosine phosphatase beta (HPTPβ), and uses thereof.

Claims (11)

1 - 24 . (canceled)

25 . A method for regulating angiogenesis in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a humanized antibody that binds HPTPbeta.

26 . The method of claim 25 , wherein the humanized antibody activates Tie-2.

27 . The method of claim 25 , wherein the humanized antibody is a monoclonal antibody.

28 . The method of claim 25 , wherein the subject has an angiogenesis elevated disorder.

29 . The method of claim 28 , wherein the angiogenesis regulated disorder is diabetic retinopathy.

30 . The method of claim 28 , wherein the angiogenesis regulated disorder is vein occlusion.

31 . The method of claim 28 , wherein the angiogenesis regulated disorder is proliferative vitreoretinopathy.

32 . The method of claim 25 , wherein the administering is parenteral.

33 . The method of claim 25 , wherein the administering is intravenous.

34 . The method of claim 25 , wherein the administering is subcutaneous.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2021
From: AERPIO PHARMACEUTICALS, INC.
To: EYEPOINT PHARMACEUTICALS, INC.
Reel/Frame 057448/0033 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 17, 2020
From: AERPIO THERAPEUTICS LLC
To: AERPIO PHARMACEUTICALS, INC.
Reel/Frame 052432/0789 →
CHANGE OF NAME Recorded Jul 31, 2019
From: AERPIO THERAPEUTICS, INC.
To: AERPIO THERAPEUTICS LLC
Reel/Frame 049920/0076 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2018
From: ROTELLO, ROCCO JAMIE; PETERS, KEVIN GENE; DAVIS, MICHAEL GLENN
To: AERPIO THERAPEUTICS, INC.
Reel/Frame 047162/0486 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2018
From: ROTELLO, ROCCO JAMIE; PETERS, KEVIN GENE; DAVIS, MICHAEL GLENN
To: AERPIO THERAPEUTICS, INC.
Reel/Frame 045250/0525 →