IP Library Granted Patent US 10,527,192
Granted Patent B2
US 10,527,192 · App. 15/898,064 · Granted Jan 7, 2020

Rotary valve

Inventors: Thomas H. Cauley, III (Redwood City, CA); John Dixon (Moss Beach, CA)
Assignee: Talis Biomedical Corporation
F16K99/0013B01L3/565B01L3/567F16K99/0028B01L2300/042F16K2099/0084
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Quick Facts
Patent No.
US 10,527,192
App. No.
15/898,064
Granted
Jan 7, 2020
Kind
B2
Abstract

Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.

Claims (19)

1. A rotary valve 00 comprising:

a. a stator 50 comprising a stator face 52 and a plurality of passages 54 , each passage comprising a port 53 at the stator face;

b. a rotor 10 operably connected to the stator and comprising a rotational axis 16 , a rotor valving face 12 , and a flow channel 40 having an inlet 41 and an outlet 42 at the rotor valving face, wherein the flow channel contains a porous solid support 45 ; and

c. a retention element 90 biasing the stator and the rotor together at a rotor-stator interface 02 to form a fluid tight seal.

2. The rotary valve of claim 1 , wherein a cross-section of the flow channel 40 is not concentric with the rotational axis 16 .

3. The rotary valve of claim 1 , wherein the porous solid support is polymeric.

4. The rotary valve of claim 1 , wherein the porous solid support is selected from the group consisting of alumina, silica, celite, ceramics, metal oxides, porous glass, controlled pore glass, carbohydrate polymers, polysaccharides, agarose, Sepharose™, Sephadex™, dextran, cellulose, starch, chitin, zeolites, synthetic polymers, polyvinyl ether, polyethylene, polypropylene, polystyrene, nylons, polyacrylates, polymethacrylates, polyacrylamides, polymaleic anhydride, membranes, hollow fibers and fibers, and any combination thereof.

5. The rotary valve of claim 1 , wherein the rotor valving face 12 comprises a gasket 80 interposed at the rotor-stator interface 02 .

6. The rotary valve of claim 5 , wherein the gasket 80 comprises an aperture 83 therethrough and wherein the stator comprises an arcing rail 70 for laterally constraining the gasket.

7. The rotary valve of claim 1 , wherein the rotor valving face comprises a fluidic connector 86 , wherein in a first rotor position a first port 53 a of the stator is fluidically connected to a second port 53 b of the stator via the fluidic connector 86 .

8. The rotary valve of claim 7 , wherein the first port is located at a first radial distance from the rotational axis and the second port is located at a second, different, radial distance.

9. The rotary valve of claim 7 , wherein in a second rotor position a third port 53 c is fluidically connected to a fourth port 53 d via the fluidic connector 86 .

10. The rotary valve of claim 1 , wherein the rotor valving face comprises a fluidic selector 87 having an arcing portion having center line arcing equidistant from the rotational axis and a radial portion extending from the arcing portion radially toward the rotational axis or away from the rotational axis.

11. The rotary valve of claim 10 , wherein in a first rotor position, a first port 53 a at a first radial distance from the rotational axis 16 is fluidically connected to a second port 53 b at a second radial distance from the rotational axis via the fluidic selector 87 , and in a second rotor position, the first port is fluidically connected to a third port 53 c at the second radial distance from the rotational axis via the fluidic selector, and wherein the first port remains fluidically connected with the fluidic selector while the rotor is rotated between the first rotor position and the second rotor position.

12. The rotary valve of claim 1 , wherein the rotor comprises a plurality of flow channels 40 , each flow channel comprising an inlet 41 , an outlet 42 , and a porous solid support 45 .

13. The rotary valve of claim 1 , wherein the rotor comprises a main body 11 and a cap 30 operably connected to the main body, and wherein one wall of the flow channel 40 is defined by the cap.

14. The rotary valve of claim 1 , further comprising a gasket 80 between the stator face 52 and the rotor valving face 12 , and wherein the stator comprises a displaceable spacer 60 for preventing the gasket from sealing against at least one of the rotor 10 and stator 50 , and wherein, when the spacer is displaced the gasket seals the rotor and stator together in a fluid-tight manner.

15. The rotary valve of claim 1 , wherein the retention element 90 comprises a retention ring 91 and a biasing element 96 .

16. The rotary valve of claim 15 , wherein the retention ring 91 is fixedly coupled to the stator 50 and the biasing element 96 is a spring biasing the rotor and stator together.

Assignments (7)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE STATE/COUNTRY ON THE COVER SHEET PREVIOUSLY RECORDED AT REEL: 66986 FRAME: 149. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Apr 11, 2024
From: TALIS BIOMEDICAL CORPORATION
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 067097/0916 →
CHANGE OF ADDRESS FROM 3400 BRIDGE PARKWAY, REDWOOD CITY TO 1100 ISLAND DRIVE, SUITE 101, REDWOOD CITY. Recorded Apr 2, 2024
From: TALIS BIOMEDICAL CORPORATION
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 066986/0144 →
CHANGE OF ADDRESS FROM 1100 ISLAND DRIVE, SUITE 101, REDWOOD CITY TO 1375 WEST FULTON MARKET, SUITE 700, CHICAGO. Recorded Apr 2, 2024
From: TALIS BIOMEDICAL CORPORATION
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 066986/0149 →
CHANGE OF ADDRESS FROM 230 CONSTITUTION DRIVE, MENLO PARK TO 3400 BRIDGE PARKWAY, REDWOOD CITY. Recorded Mar 27, 2024
From: TALIS BIOMEDICAL CORPORATION
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 066926/0028 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2018
From: CAULEY, THOMAS H., III; DIXON, JOHN
To: SLIPCHIP CORPORATION
Reel/Frame 045482/0619 →
CHANGE OF NAME Recorded Apr 9, 2018
From: SLIPCHIP CORPORATION
To: TALIS BIOMEDICAL, INC.
Reel/Frame 046437/0839 →
CHANGE OF NAME Recorded Apr 9, 2018
From: TALIS BIOMEDICAL, INC.
To: TALIS BIOMEDICAL CORPORATION
Reel/Frame 046437/0850 →
Continuity (1)
Related Publication 20190249799A1 · Aug 15, 2019
Cited By (2)
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