IP Library › Granted Patent US 10,287,552
Granted Patent B2
US 10,287,552 · App. 15/900,834 · Granted May 14, 2019

Generation of hepatocytes from pluripotent stem cells

Inventors: Sanjeev Gupta (Scarsdale, NY); Sriram Bandi (Belleville, NJ)
Assignee: Albert Einstein College of Medicine
C12N5/067A61K35/407C12N5/0672C12N2500/84C12N2501/999C12N2502/14C12N2506/02
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Quick Facts
Patent No.
US 10,287,552
App. No.
15/900,834
Granted
May 14, 2019
Kind
B2
Abstract

Methods are provided for producing differentiated cells from stem cells, including producing hepatocytes. Compositions thereof are also provided, as are methods of treating a liver disorder.

Claims (11)

1. A composition comprising:

L-cysteinglutathione disulfide,

γ-Glu-Cys,

DL-kynurenine,

D-penicillamine disulfide,

phenacetin,

phytosphingosine HCl,

pyridoxal HCl,

optionally, an additional antibiotic.

2. The composition of claim 1 , wherein the additional antibiotic is tetracaine HCl.

3. The composition of claim 1 , which does not contain the additional antibiotic.

Assignments (1)
MERGER AND CHANGE OF NAME Recorded Feb 26, 2019
From: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.; ALBERT EINSTEIN COLLEGE OF MEDICINE
To: ALBERT EINSTEIN COLLEGE OF MEDICINE
Reel/Frame 048438/0275 →
Continuity (3)
Division 14409234
Provisional Application 61666219 · Jun 29, 2012
Related Publication 20180208892A1 · Jul 26, 2018