Acoustic energy-based control of particle count in crystallization
Methods and systems for preparing crystalline particle compositions using focused acoustic processing to control a number or count of crystalline particles generated. Peak incident power of focused acoustic energy used to cause primary nucleation kinetics of a solute may be adjusted to adjust the number or count of crystalline particles.
1. A method of preparing crystalline particles, comprising:
providing a solute in a solution at a concentration and at a temperature below that required for primary nucleation of the solute to form crystalline particles to occur;
exposing the solution to focused acoustic energy arranged to cause the solute to form crystalline particles in the solution by primary or secondary nucleation; and
adjusting a total number of crystalline particles that are formed by primary nucleation per unit volume by adjusting a peak incident power (PIP) of the focused acoustic energy.
2. The method of claim 1 , wherein the temperature at which the solution is maintained during the steps of exposing and adjusting is constant.
3. The method of claim 1 , wherein the concentration and the temperature are below that required for secondary nucleation.
4. The method of claim 1 , wherein the step of adjusting includes increasing the PIP to increase the total number of crystalline particles that are formed per unit volume, or decreasing the PIP to decrease the total number of crystalline particles that are formed per unit volume.
5. The method of claim 1 , wherein the solution flows into an inlet of an acoustic energy treatment chamber and flows out of an outlet of the acoustic energy treatment chamber.
6. The method of claim 5 , wherein the solution flows from a feed reactor vessel to the inlet of the acoustic energy treatment chamber, and flows from the outlet of the acoustic energy treatment chamber to a mixed-suspension, mixed-product-removal (MSMPR) vessel.
7. The method of claim 6 , further comprising measuring a size or number of crystalline particles in at least a portion the solution in the MSMPR vessel, and using the measured size or number of crystalline particles to adjust the PIP of the focused acoustic energy.
8. The method of claim 5 , wherein the solution is exposed to a focal zone of the focused acoustic energy while disposed in the acoustic energy treatment chamber.
9. The method of claim 5 , wherein the inlet of the acoustic energy treatment chamber is in direct fluid communication with a supply reservoir and the outlet of the acoustic energy treatment chamber is in direct fluid communication with an outlet reservoir.
10. The method of claim 1 , wherein the crystalline particles each have a size below 1000 microns.
11. The method of claim 1 , further comprising using the crystalline particles to induce secondary nucleation in the solution.
12. The method of claim 1 , wherein the focused acoustic energy has a frequency of between about 100 kilohertz and about 100 megahertz and a focal zone having a size dimension of less than about 2 milliliters.