Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
1. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:
i. a dicarboxylic acid ester;
ii. about 0.1% to about 5% by weight of the carrier of at least one surface-active agent;
iii. about 2% to about 50% by weight of the carrier of at least one hydrophobic solvent; and
iv. water,
wherein the composition does not comprise a polymeric gelling agent; and
wherein upon release from a foam dispenser, a foam is produced.
2. The foamable composition of claim 1 , wherein the carrier is an emulsion.
3. The foamable composition of claim 1 , wherein the at least one surface-active agent has a hydrophilic/lipophilic balance (HLB) value of between about 9 and about 14.
4. The foamable composition of claim 1 , further comprising a retinoid.
5. The foamable composition of claim 4 , wherein the dicarboxylic acid ester is diisopropyl adipate and the at least one hydrophobic solvent is mineral oil.