Tricyclic heterocycles as BET protein inhibitors
The present invention relates to tricyclic heterocycles of Formula (I): which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
represents a double bond;
L is O;
Cy 1 is selected from phenyl or a 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, wherein said phenyl or 5-6 membered heteroaryl of Cy 1 is optionally substituted with 1, 2, 3, or 4 groups independently selected from R 11 ;
R 1 and R 2 are independently selected from H, halo, CN, OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, OR a1 , SR a1 , C(═O)R b1 , C(═O)NR c1 R d1 , C(═O)OR a1 , OC(═O)R b1 , OC(═O)NR c1 R d1 , NR c1 R d1 , NR c1 C(═O)R b1 , NR c1 C(═O)NR c1 R d1 , NR c1 C(═O)OR a1 , S(═O)R b1 , S(═O)NR c1 R d1 , S(═O) 2 R b1 , NR c1 S(═O)) 2 R b1 and S(═O) 2 NR c1 R d1 , wherein said C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl of R 1 and R 2 are optionally substituted with 1, 2, or 3 groups independently selected from halo, CN, OH, OR a1 , SR a1 , C(═O)R b1 , C(═O)NR c1 R d1 , C(═O)OR a1 , OC(═O)R b1 , OC(═O)NR c1 R d1 ; NR c1 R d1 , NR c1 C(═O)R b1 , NR c1 C(═O)NR c1 R d1 , NR c1 C(═O)R a1 , S(═O)R b1 , S(═O)NR c1 R d1 ; S(═O) 2 R b1 , NR c1 S(═O) 2 R b1 and S(═O) 2 NR c1 R d1 ;
provided neither R 1 nor R 2 are Cl, Br, I, CN, or OH when L is O or S;
alternatively, R 1 and R 2 together with the carbon atom to which they are attached are combined to form a C 3-7 cycloalkyl group, wherein said cycloalkyl group is optionally substituted with 1, 2, 3, or 4 groups independently selected from R 20 ;
Cy 3 is selected from phenyl, C 3-7 cycloalkyl, a 5-10 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 4-10 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said phenyl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of Cy 3 is optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 , wherein a ring-forming nitrogen atom of said 5-10 membered heteroaryl group or a ring-forming nitrogen atom of said 4-10 membered heterocycloalkyl group is optionally oxidized;
R 4 is H, C(═O)NR 14a R 14b , C(═O)R 14a , C(═O)OR 14a , or C 1-6 alkyl optionally substituted by 1, 2, or 3 substituents independently selected from halo, NR 14a R 14b , OR 14a , SR 14a , CN, C(═O)R 14a , C(═O)NR 14a R 14b , C(═O)OR 14a , OC(═O)R 14b , OC(═O)NR 14a R 14b , NR 14a C(═O)R 14b , NR 14a C(═O)NR 14a R 14b , NR 14a C(═O)OR 14b , S(═O)R 14a , S(═O)NR 14a R 14b , S(═O) 2 R 14a , NR 14a S(═O) 2 R 14b , and S(═O) 2 NR 14a R 14b ;
R 5 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, NR 15a R 15b , —C(═O)NR 15a R 15b , —C(═O)OR 15a , phenyl, C 3-7 cycloalkyl, 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 4-10 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said C 1-6 alkyl, phenyl, C 3-7 cycloalkyl, 5-6 membered heteroaryl, and 4-10 membered heterocycloalkyl of R 5 is optionally substituted by 1, 2, 3, or 4 groups independently selected from R 15 ;
R 6 is absent;
R 7 is selected from H, halo, CN, OR a , NR c R d , SR b , C(═O)NR c R d , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, phenyl, C 3-7 cycloalkyl, 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 4-7 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, phenyl, C 3-7 cycloalkyl, 5-6 membered heteroaryl group, and a 4-7 membered heterocycloalkyl group of R 7 are optionally substituted with 1, 2, or 3 groups independently selected from R 17 ;
R 8 is selected from H, C 1-3 alkyl, C 2-3 alkenyl, C 2-3 alkynyl, C 1-3 haloalkyl, halo, CN, OR a , NR c R d , SR b , and C(═O)NR c R d , wherein said C 1-3 alkyl of R 8 is optionally substituted with 1, 2, or 3 groups independently selected from R 18 ;
R 9 and R 9a are independently selected from H, C 1-3 alkyl, C 1-3 haloalkyl, halo, CN, OR a , NR c R d , SR b , and C(═O)NR c R d ;
R 11 is independently at each occurrence selected from H, C 1-3 alkyl, C 1-3 haloalkyl, halo, CN, OR a , NR c R d , SR b , and C(═O)NR c R d , wherein said C 1-3 alkyl is optionally substituted by OH;
R 13 is independently at each occurrence selected from H, halo, CN, OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, OR a3 , SR a3 , C(═O)R b3 , C(═O)NR c3 R d3 , C(═O)OR a3 , OC(═O)R b3 , OC(═O)NR c3 R d3 , NR c3 R d3 , NR c3 C(═O)R b3 , NR c3 C(═O)NR c3 R d3 , NR c3 C(═O)OR a3 , S(═O)R b3 , S(═O)NR c3 R d3 , S(═O) 2 R b3 , NR c3 S(═O) 2 R b3 and S(═O) 2 NR c3 R d3 , wherein said C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl of R 13 is optionally substituted with 1, 2, or 3 groups independently selected from halo, CN, OH, OR a3 , SR a3 , C(═O)R b3 , C(═O)NR c3 R d3 , C(═O)OR a3 , OC(═O)R b3 , OC(═O)NR c3 R d3 , NR c3 R d3 , NR c3 C(═O)R b3 , NR c3 C(═O)NR c3 R d3 , NR c3 C(═O)OR a3 , S(═O)R b3 , S(═O)NR c3 R d3 , S(═O) 2 R b3 , NR c3 S(═O) 2 R b3 and S(═O) 2 NR c3 R d3 ;
R 15 is independently at each occurrence selected from H, C 1-6 alkyl, C 3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, halo, CN, OR a5 , SR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(O)OR a5 , S(═O)R b5 , S(═O)NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 , and S(═O) 2 NR c5 R d5 , wherein said C 1-6 alkyl, C 3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, CN, OR a5 , SR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , S(═O)R b5 , S(═O)NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 , S(═O) 2 NR c5 R d5 , 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl, and C 3-7 cycloalkyl;
R 14a and R 14b are independently at each occurrence selected from H and C 1-6 alkyl, wherein said C 1-6 alkyl of R 14a and R 14b is optionally substituted with 1, 2, or 3 substituents selected from R 20 ;
or R 14a and R 14b together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl ring optionally substituted with 1, 2, or 3 substituents selected from R 20 ;
R 15a and R 15b are independently at each occurrence selected from H and C 1-6 alkyl, wherein said C 1-6 alkyl of R 15a and R 15b is optionally substituted with 1, 2, or 3 substituents selected from R 20 ;
or R 15a and R 15b together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl ring optionally substituted with 1, 2, or 3 substituents selected from R 20 ;
R 17 and R 18 are independently at each occurrence selected from halo, C 1-4 alkyl, CN, OR a , NR c R d , SR b , C(═O)NR c R d , C(═O)OR a , and NR c C(═O)R a ;
R a , R c , and R d are independently at each occurrence selected from H, C 1-6 alkyl, C(O)R e , S(═O) 2 R f , C(═O)NR g R h , and phenyl optionally substituted by C 1-4 alkoxy;
R b is at each occurrence C 1-6 alkyl;
R e is at each occurrence C 1-4 alkyl optionally substituted by a group selected from phenyl, C 1-4 alkoxy, amino, C 1-4 alkylamino, and C 2-8 dialkylamino;
R f is C 1-4 alkyl;
R g and R h are independently at each occurrence selected from H and C 1-4 alkyl;
R a1 , R b1 , R c1 and R d1 are independently at each occurrence selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-6 haloalkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl forming R a1 , R b1 , R c1 and R d1 are each optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ;
R a3 , R b3 , R c3 and R d3 are independently at each occurrence selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, and C 1-6 haloalkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl forming R a3 , R b3 , R c3 and R d3 are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, OR a4 , SR a4 , C(═O)R b4 , C(═O)NR c4 R d4 , C(═)OR a4 , OC(═O)R b4 , OC(═O)NR c4 R d4 , NR c4 R d4 , NR c4 C(═O)R b4 , NR c4 C(═O)NR c4 R d4 , NR c4 C(═O)OR a4 , S(O)R b4 , S(═O)NR c4 R d4 , S(═O) 2 R b4 , NR c4 S(═O) 2 R b4 and S(═O) 2 NR c4 R d4 ;
R a4 , R b4 , R c4 and R d4 are independently at each occurrence selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-6 haloalkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl forming R a4 , R b4 , R c4 and R d4 are each optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ;
R a5 , R b5 , R c5 and R d5 are independently at each occurrence selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, 5-6 membered heterocycloalkyl, and C 1-6 haloalkyl wherein said C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl forming R a5 , R b5 , R c5 and R d5 are each optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ;
or R c5 and R d5 together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl ring optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ; and
R 20 is at each occurrence independently selected from H, halo, OH, CN, amino, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 alkyl-C(═O)—, C 1-4 alkyl-C(═O)O—, C 1-4 alkyl-OC(═O)—, HOC(═O)—, H 2 NC(═O)—, C 1-4 alkyl-NHC(═O)—, di(C 1-4 alkyl)NC(═O)—, C 1-4 alkyl-C(═O)NH—, C 1-4 alkyl-O—C(═O)NH—, C 1-4 alkyl-S(═O)—, H 2 NS(═O)—, C 1-4 alkyl-NHS(═O)—, di(C 1-4 alkyl)NS(═O)—, C 1-4 alkyl-S(═O) 2 —, C 1-4 alkyl-S(═O) 2 NH—, H 2 NS(═O) 2 —, C 1-4 alkyl-NHS(═O) 2 —, and di(C 1-4 alkyl)NS(═O) 2 —.
2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein:
represents a double bond;
L is O;
Cy 1 is a five membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, wherein said five membered heteroaryl of Cy 1 is optionally substituted with 1, 2, or 3 groups independently selected from R 11 ;
R 1 is selected from H, F, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, OR a1 , C(═O)R b1 , C(═O)NR c1 R d1 , and C(O)OR a1 ;
R 2 is selected from H, F, and C 1-6 alkyl;
Cy 3 is selected from phenyl, C 3-7 cycloalkyl, a 5-10 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 4-10 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said phenyl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of Cy 3 is optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 ; additionally, wherein a ring-forming nitrogen atom of said 5-10 membered heteroaryl group or a ring-forming nitrogen atom of said 4-10 membered heterocycloalkyl group is optionally oxidized;
R 4 is H or C 1-6 alkyl;
R 5 is selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, NR 15a R 15b , phenyl, C 3-7 cycloalkyl, 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 4-7 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said C 1-6 alkyl, phenyl, C 3-7 cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl of R 5 is optionally substituted by 1, 2, 3, or 4 groups independently selected from R 15 ;
R 6 is absent;
R 7 is selected from H, halo, CN, C 1-6 alkyl, C 1-6 alkoxy, phenyl, and 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, wherein said C 1-6 alkyl, phenyl, or 5-6 membered heteroaryl group, of R 7 are optionally substituted with 1, 2, or 3 groups independently selected from R 17 ;
R 8 is selected from H, halo, CN, OH, and C 1-6 alkyl;
R 11 is independently at each occurrence selected from H, C 1-3 alkyl, C 1-3 haloalkyl, halo, CN, OR a , NR c R d , SR b , and C(═O)NR c R d ;
R 13 is independently at each occurrence selected from H, halo, CN, OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, OR a3 , SR a3 , C(═O)R b3 , C(═O)NR c3 R d3 , C(═O)OR a3 , OC(═O)R b3 , OC(═O)NR c3 R d3 , NR c3 R d3 , NR c3 C(═O)R b3 , NR c3 C(═O)NR c3 R d3 , NR c3 C(═O)OR a3 , S(═O)R b3 , S(═O)NR c3 R d3 , S(═O) 2 R b3 , NR c3 S(═O) 2 R b3 and S(═O) 2 NR c3 R d3 , wherein said C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl of R 13 is optionally substituted with 1, 2, or 3 groups independently selected from halo, CN, OH, OR a3 , SR a3 , C(═O)R b3 , C(═O)NR c3 R d3 , C(═O)OR a3 , OC(═O)R b3 , OC(═O)NR c3 R d3 , NR c3 R d3 , NR c3 C(═O)R b3 , NR c3 C(═O)NR c3 R d3 , NR c3 C(═O)OR a3 , S(═O)R b3 , S(═O)NR c3 R d3 , S(═O) 2 R b3 , NR c3 S(═O) 2 R b3 and S(═O) 2 NR c3 R d3 ;
R 15 is independently at each occurrence selected from H, halo, CN, OH, OR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , NR c5 R d5 , and NR c5 C(═O)R b5 ;
R 15a and R 15b are independently selected from H and C 1-6 alkyl, wherein said C 1-6 alkyl of R 15a and R 15b is optionally substituted with 0, 1, 2, or 3 substituents selected from R 20 ;
R 17 is independently at each occurrence selected from halo, CN, OR a , NR c R d , SR b , and C(═O)NR c R d ;
R a , R c , and R d are independently at each occurrence selected from H and C 1-6 alkyl;
R b is at each occurrence C 1-6 alkyl;
R a1 , R b1 , R c1 and R d1 are independently at each occurrence selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 1-6 haloalkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl forming R a1 , R b1 , R c1 and R d1 are each optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ;
R a3 , R b3 , R c3 and R d3 are independently at each occurrence selected from H and C 1-6 alkyl, wherein said C 1-6 alkyl forming R a3 , R b3 , R c3 and R d3 is optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, OR a4 , SR a4 , C(═O)R b4 , C(═O)NR c4 R d4 , C(═O)R a4 , OC(═O)R b4 , OC(═O)NR c4 R d4 , NR c4 R d4 , NR c4 C(═O)R b4 , NR c4 C(═O)NR c4 R d4 , NR c4 C(═O)OR a4 , S(═O)R b4 , S(═O)NR c4 R d4 , S(═O) 2 R b4 , NR c4 S(═O) 2 R b4 and S(═O) 2 NR c4 R d4 ;
R a4 , R b4 , R c4 and R d4 are independently at each occurrence selected from H and C 1-6 alkyl, wherein said C 1-6 alkyl forming R a4 , R b4 , R c4 and R d4 is optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ;
R a5 , R b5 , R c5 and R d5 are independently at each occurrence selected from H and C 1-6 alkyl, wherein said C 1-6 alkyl forming R a5 , R b5 , R c5 and R d5 is optionally substituted with 1, 2, or 3 substituents independently selected from R 20 ; and
R 20 is at each occurrence independently selected from H, halo, OH, CN, amino, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkylamino, di(C 1-4 alkyl)amino, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 alkyl-C(═O)—, C 1-4 alkyl-C(═O)O—, C 1-4 alkyl-OC(═O)—, HOC(═O)—, H 2 NC(═O)—, C 1-4 alkyl-NHC(═O)—, di(C 1-4 alkyl)NC(═O)—, C 1-4 alkyl-C(═O)NH—, C 1-4 alkyl-S(═O)—, H 2 NS(═O)—, C 1-4 alkyl-NHS(═O)—, di(C 1-4 alkyl)NS(═O)—, C 1-4 alkyl-S(═O) 2 —, C 1-4 alkyl-S(═O) 2 NH—, H 2 NS(═O) 2 —, C 1-4 alkyl-NHS(═O) 2 —, and di(C 1-4 alkyl)NS(═O) 2 —.
3. The compound of claim 1 having Formula (Ia):
or a pharmaceutically acceptable salt thereof, wherein:
represents a double bond;
Cy 1 is selected from isoxazolyl and pyrazolyl, wherein said isoxazolyl and pyrazolyl of Cy 1 is optionally substituted with 1 or 2 groups independently selected from R 11 ;
R 1 is selected from H, methyl, —C(═O)OCH 2 CH 3 , —C(═O)N(H)CH 2 CH 3 , —C(═O)N(H)CH 2 CH 2 OH, and —C(═O)N(CH 3 ) 2 ;
Cy 3 is selected from phenyl, pyridinyl, oxidopyridinyl, thiazolyl, cyclohexyl, dihydrobenzofuranyl and tetrahydrofuranyl, wherein said phenyl, pyridinyl, oxidopyridinyl, thiazolyl, cyclohexyl, dihydrobenzofuranyl and tetrahydrofuranyl of Cy 3 is optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 ;
R 5 is H, methyl, —CH═CH 2 , —N(H)CH 3 , —N(H)CH 2 CH 3 , —N(H)CH(CH 3 ) 2 , —N(CH 3 ) 2 , —N(H)CH 2 CH 2 OH, —N(H)CH(CH 3 )CH 2 OH, —N(H)CH 2 CH(OH)CH 3 , —N(H)C(CH 3 ) 2 CH 2 OH, —N(CH 3 )CH 2 CH 2 OH, morpholinyl, pyrrolidinyl, hydroxypyrrolidinyl, piperidinyl, hydroxypiperidinyl, azetidinyl, hydroxyazetidinyl, piperazinyl, butoxycarbonylpiperazinyl, and phenyl;
R 6 is absent;
R 7 is selected from H, F, Cl, Br, methyl, methoxy, ethoxy, CN, phenyl, and pyridinyl;
R 11 is independently at each occurrence selected from H, methyl, ethyl, chloro, and methoxy; and
R 13 is independently at each occurrence selected from H, F, CN, methoxy, —CF 3 , —OCH 2 C(═O)OH, —OCH 2 C(═O)N(H)CH 2 CH 3 , —OCH 2 C(═O)N(H)CH 2 CH 2 OH, and —OCH 2 C(═O)N(CH 3 ) 2 .
4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 1 is isoxazolyl substituted with 1 or 2 groups independently selected from R 11 .
5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 1 is pyrazolyl substituted with 1 or 2 groups independently selected from R 11 .
6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from H, methyl, —CH 2 OH, —C(═O)OCH 2 CH 3 , —C(═O)N(H)CH 2 CH 3 , —C(═O)N(H)CH 3 , —C(═O)NH 2 , —C(═O)N(H)CH 2 CH 2 OH, and —C(═O)N(CH 3 ) 2 .
7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from H, methyl, —C(═O)OCH 2 CH 3 , —C(═O)N(H)CH 2 CH 3 , —C(═O)N(H)CH 2 CH 2 OH, and —C(═O)N(CH 3 ) 2 .
8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is H.
9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is methyl.
10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is —C(═O)OCH 2 CH 3 .
11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is C(═O)N(H)CH 2 CH 3 .
12. The compound of any claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is C(═O)N(H)CH 2 CH 2 OH.
13. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is —C(═O)N(CH 3 ) 2 .
14. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is —C(═O)N(H)CH 3 .
15. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is —C(═O)NH 2 .
16. The compound claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is —CH 2 OH.
17. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is H.
18. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is methyl.
19. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is selected from phenyl, pyridinyl, oxidopyridinyl, thiazolyl, cyclohexyl, dihydrobenzofuranyl, tetrahydrofuranyl, and piperinyl, wherein said phenyl, pyridinyl, oxidopyridinyl, thiazolyl, cyclohexyl, dihydrobenzofuranyl, tetrahydrofuranyl, and piperidinyl of Cy 3 is optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
20. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is selected from phenyl, pyridinyl, oxidopyridinyl, thiazolyl, cyclohexyl, dihydrobenzofuranyl and tetrahydrofuranyl, wherein said phenyl, pyridinyl, oxidopyridinyl, thiazolyl, cyclohexyl, dihydrobenzofuranyl and tetrahydrofuranyl of Cy 3 is optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
21. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is phenyl optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
22. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is pyridinyl optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
23. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is oxidopyridinyl optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
24. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is thiazolyl optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
25. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is cyclohexyl optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
26. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is dihydrobenzofuranyl optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
27. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is tetrahydrofuranyl optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
28. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy 3 is piperidinyl optionally substituted with 1, 2, 3, or 4 groups independently selected from R 13 .
29. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is H, —C(═O)NH 2 , —CH 2 NH 2 , —CH 2 N(H)C(═O)CH 3 , —C(═O)N(H)CH 3 , —CH 2 CH 3 , or —CH 3 .
30. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is H.
31. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is selected from H, C 1-4 alkyl, —CH═CH 2 , NR 15a R 15b , C(═O)NR 15a R 15b , phenyl, and a 4-10 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said C 1-4 alkyl, and 4-10 membered heterocycloalkyl of R 5 is optionally substituted by 1 or 2 groups independently selected from R 15 .
32. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is selected from H, C 1-4 alkyl, —CH═CH 2 , NR 15a R 15b , C(═O)NR 15a R 15b , phenyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, 1,2,3,6-tetrahydropyridinyl, 2,5-dihydro-1H-pyrrolyl, 1,4-diazepanyl, morpholinyl, and octahydropyrrolo[1,2-a]pyrazinyl, wherein said C 1-4 alkyl, phenyl, azetidinyl, pyrolidinyl, piperidinyl, piperazinyl, 1,2,3,6-tetrahydropyridinyl, 2,5-dihydro-1H-pyrrolyl, 1,4-diazepanyl, morpholinyl, and octahydropyrrolo[1,2-a]pyrazinyl of R 5 is optionally substituted by 1 or 2 groups independently selected from R 15 .
33. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is H, methyl, —CH═CH 2 , —N(H)CH 3 , —N(H)CH 2 CH 3 , —N(H)CH(CH 3 ) 2 , —N(CH 3 ) 2 , —N(H)CH 2 CH 2 OH, —N(H)CH(CH 3 )CH 2 OH, —N(H)CH 2 CH(OH)CH 3 , —N(H)C(CH 3 ) 2 CH 2 OH, —N(CH 3 )CH 2 CH 2 OH, morpholinyl, pyrrolidinyl, hydroxypyrrolidinyl, piperidinyl, hydroxypiperidinyl, azetidinyl, hydroxyazetidinyl, piperazinyl, butoxycarbonylpiperazinyl or phenyl.
34. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is selected from a 4-6 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said 4-6 membered heterocycloalkyl of R 5 is optionally substituted by 1 or 2 groups independently selected from R 15 .
35. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is pyrrolidinyl, piperidinyl, azetidinyl, or piperazinyl, wherein said pyrrolidinyl, piperidinyl, azetidinyl, or piperazinyl of R 5 is optionally substituted by 1 or 2 groups independently selected from R 15 .
36. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is pyrrolidinyl, wherein said pyrrolidinyl of R 5 is optionally substituted by 1 or 2 groups independently selected from R 15 .
37. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is piperidinyl, wherein said piperidinyl of R 5 is optionally substituted by 1 or 2 groups independently selected from R 15 .
38. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is azetidinyl, wherein said azetidinyl of R 5 is optionally substituted by 1 or 2 groups independently selected from R 15 .
39. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is piperazinyl, wherein said piperazinyl of R 5 is optionally substituted by 1 or 2 groups independently selected from R 15 .
40. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 15 is independently at each occurrence selected from C 1-6 alkyl, CN, OR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 , and S(═O) 2 NR c5 R d5 , wherein said C 1-6 alkyl, is optionally substituted by 1, 2, or 3 substituents independently selected from halo, CN, OR a5 , SR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , S(═O)R b5 , S(═O)NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 , S(═O) 2 NR c5 R d5 , 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl, and C 3-7 cycloalkyl.
41. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein IC is selected from H, halo, CN, NR c R d , C 1-6 alkyl, C 2-6 alkenyl, 5-6 membered heteroaryl group comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O and S, and a 5-6 membered heterocycloalkyl group comprising carbon and 1, 2, or 3 heteroatoms selected from N, O and S, wherein said C 1-6 alkyl, C 2-6 alkenyl, 5-6 membered heteroaryl group, and 5-6 membered heterocycloalkyl group of IC are optionally substituted with 1, 2, or 3 groups independently selected from R 17 .
42. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 selected from H, F, Cl, Br, CN, NR c R d , C 1-4 alkyl, C 2-4 alkenyl, pyrazolyl, pyridinyl, pyrimidinyl, and 1,2,3,6-tetrahydropyridinyl, wherein said C 1-4 alkyl, C 2-4 alkenyl, pyrazolyl, pyridinyl, pyrimidinyl, and 1,2,3,6-tetrahydropyridinyl of R 7 are optionally substituted with 1, 2, or 3 groups independently selected from R 17 .
43. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is selected from H, halo, C 1-4 alkyl, and CN.
44. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is selected from H, Br, methyl, and CN.
45. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is H.
46. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is Br.
47. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is methyl.
48. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is CN.
49. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 8 is selected from H, halo, C 1-4 alkyl, and CN.
50. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 8 is H.
51. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having Formula (IIIb):
52. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having Formula (IVb):
53. The compound of claim 1 selected from:
7-(3,5-dimethylisoxazol-4-yl)-2-methyl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
7-(3,5-Dimethylisoxazol-4-yl)-N-isopropyl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine;
7-(3,5-Dimethylisoxazol-4-yl)-N-methyl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine;
7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine;
7-(3,5-Dimethylisoxazol-4-yl)-N,N-dimethyl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine;
2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]amino}ethanol;
2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]amino}propan-1-ol;
1-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]amino}propan-2-ol;
2-1 [7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]amino-2-methylpropan-1-ol;
2-[[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl](methyl)amino]ethanol;
7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
7-(3,5-dimethylisoxazol-4-yl)-4-phenyl-2-piperazin-1-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
7-(3,5-dimethylisoxazol-4-yl)-2,4-diphenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
7-(3,5-Dimethylisoxazol-4-yl)-2-morpholin-4-yl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-2-pyrrolidin-1-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
1-[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-ol;
7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-2-piperidin-1-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
1-[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-ol;
1-[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-3-ol;
1-[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-ol; and
4-[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazine-1-carboxylate;
or a pharmaceutically acceptable salt thereof.
54. The compound of claim 1 , selected from:
(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-2-vinyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(1R)-1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]ethane-1,2-diol;
1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]ethanol;
(4S)-7-(3,5-Dimethylisoxazol-4-yl)-N,N-dimethyl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-2-carboxamide;
(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
tert-Butyl (4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-2-carboxylate;
(4S)-7-(3,5-Dimethylisoxazol-4-yl)-2-(morpholin-4-ylcarbonyl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-Dimethylisoxazol-4-yl)-N-methyl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-2-carboxamide;
(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-2-carboxamide;
tert-Butyl 4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-3,6-dihydropyridine-1(2H)-carboxylate;
tert-Butyl 3-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-2,5-dihydro-1H-pyrrole-1-carboxylate;
tert-Butyl 5-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-3,6-dihydropyridine-1(2H)-carboxylate;
tert-Butyl 4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidine-1-carboxylate;
tert-Butyl 3-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidine-1-carboxylate;
tert-Butyl 3-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidine-1-carboxylate;
(4S)-2-(1-Acetylpiperidin-4-yl)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-2-(1,2,3,6-tetrahydropyridin-4-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-(2,5-dihydro-1H-pyrrol-3-yl)-′7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-2-pyrrolidin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-2-(1,2,5,6-tetrahydropyridin-3-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-piperidin-3-yl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-(1-Acetylpiperidin-4-yl)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-[1-(cyclopropylcarbonyl)piperidin-4-yl]-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[1-(methylsulfonyl)piperidin-4-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-(1-acetylpyrrolidin-3-yl)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-[1-(cyclopropylcarbonyl)pyrrolidin-3-yl]-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[1-(methylsulfonyl)pyrrolidin-3-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-(1-acetyl-1,2,5,6-tetrahydropyridin-3-yl)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-(1-acetylpiperidin-3-yl)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo [1,5,4-de][1,4]benzoxazine;
(4S)-2-[1-(cyclopropylcarbonyl)piperidin-3-yl]-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[1-(methylsulfonyl)piperidin-3-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(3R)-1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N-isopropylpyrrolidine-3-carboxamide;
1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-3-methylpyrrolidin-3-ol;
4-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-1,4-diazepane-1-sulfonamide;
(4S)-2-(4-Acetyl-1,4-diazepan-1-yl)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo [1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-Dimethylisoxazol-4-yl)-2-[4-(methylsulfonyl)-1,4-diazepan-1-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-Dimethylisoxazol-4-yl)-2-piperazin-1-yl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
2-{4-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazin-1-yl}-N,N-dimethylacetamide;
2-Cyano-N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}-N-methylacetamide;
N-{(3R)-1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}morpholine-4-carboxamide;
7-(3,5-Dimethylisoxazol-4-yl)-2-methyl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
Methyl {(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}carbamate;
7-(3,5-Dimethylisoxazol-4-yl)-9-fluoro-N,N-dimethyl-4-pyridin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine;
1-[7-(3,5-Dimethylisoxazol-4-yl)-9-fluoro-4-pyridin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-ol;
7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-9-fluoro-4-pyridin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine;
(3R)-1-[7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-ol;
1-[7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-ol;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-morpholin-4-yl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-2-pyrrolidin-1-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-(4-methylpiperazin-1-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-azetidin-1-yl-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-ol;
4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-1-methylpiperazin-2-one;
ethyl 4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazine-1-carboxylate;
(3R)-1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-ol;
(3 S)-1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-ol;
1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-ol;
(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-3-ol;
(3S)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-3-ol;
1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N,N-dimethylpiperidin-4-amine;
4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazin-2-one;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[4-(methylsulfonyl)piperazin-1-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-(4-isopropylpiperazin-1-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidine-4-carbonitrile;
{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-yl}methanol;
2-{4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazin-1-yl}ethanol;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-(4-phenylpiperazin-1-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-2-(4-benzylpiperazin-1-yl)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N,N-dimethylpyrrolidin-3-amine;
(3S)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N,N-dimethylpyrrolidin-3-amine;
(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N-methylpyrrolidin-3-amine;
(3S)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N-methylpyrrolidin-3-amine;
tert-butyl {(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}carbamate;
tert-butyl {(3S)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}carbamate;
(4S)-2-[4-(cyclopropylmethyl)piperazin-1-yl]-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[4-(2-methoxyethyl)piperazin-1-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
2-[[7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl](methyl)amino]ethanol;
7-(3,5-dimethylisoxazol-4-yl)-N-methyl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine;
7-(3,5-dimethylisoxazol-4-yl)-N,N-dimethyl-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-amine;
1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidine-4-carboxamide;
1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N-methylpiperidine-4-carboxamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-yl}acetamide;
2-{4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazin-1-yl}acetamide;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-(4-ethylpiperazin-1-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[(8aS)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-4-methylpiperidin-4-ol;
4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-3-methylpiperazin-2-one;
tert-butyl {1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}carbamate;
tert-butyl 4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-1,4-diazepane-1-carboxylate;
2-{[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]amino}ethanol;
tert-butyl (2-{[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]amino}ethyl)carbamate;
N-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]ethane-1,2-diamine;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}acetamide;
N-{(3 S)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}acetamide;
(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-amine;
(3S)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-amine;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}-2,2,2-trifluoroacetamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}-2-methoxyacetamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}cyclopropanecarboxamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}methanesulfonamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}propanamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}-2-methylpropanamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}cyclobutanecarboxamide;
2-cyano-N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}acetamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}tetrahydro-2H-pyran-4-carboxamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}ethanesulfonamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}propane-1-sulfonamide;
N′-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}-N,N-dimethylurea;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}propane-2-sulfonamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}cyclopropanesulfonamide;
methyl {(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}methylcarbamate;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}-N-methylmethanesulfonamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}-2-methoxy-N-methylacetamide;
N-{(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidin-3-yl}-N-methylacetamide;
(4S)-2-(4-acetylpiperazin-1-yl)-′7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-(4-propionylpiperazin-1-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[4-(ethylsulfonyl)piperazin-1-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
4-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperazine-1-sulfonamide;
1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-amine;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}acetamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}propanamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}-2-methylpropanamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}-2-methoxyacetamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}cyclopropanecarboxamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}cyclobutanecarboxamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}methanesulfonamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}ethanesulfonamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]azetidin-3-yl}propane-2-sulfonamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-yl}methanesulfonamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-yl}-2-methoxyacetamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-yl}-2,2,2-trifluoroacetamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-yl}propanamide;
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]piperidin-4-yl}propanamide;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-(4-propionyl-1,4-diazepan-1-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(4S)-7-(3,5-dimethylisoxazol-4-yl)-2-[4-(ethylsulfonyl)-1,4-diazepan-1-yl]-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine;
(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N-methylpyrrolidine-3-carboxamide;
(3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]-N-ethylpyrrolidine-3-carboxamide; and
(3R)—N-cyclopropyl-1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]pyrrolidine-3-carboxamide;
or a pharmaceutically acceptable salt thereof.
55. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
56. A method of inhibiting a BET protein in vitro comprising contacting a compound of claim 1 , or a pharmaceutically acceptable salt thereof, with said BET protein.