IP Library › Granted Patent US 10,328,088
Granted Patent B2
US 10,328,088 · App. 15/907,566 · Granted Jun 25, 2019

Use of aminosalicylates in diarrhoea-predominent irritable bowel syndrome

Inventor: Nicolas Peter Shortis (Pymble, AU)
Assignee: Salix Pharmaceuticals, Inc.
A61K31/655A61K31/166A61K31/437A61K31/606A61K31/635A61K45/06
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Quick Facts
Patent No.
US 10,328,088
App. No.
15/907,566
Granted
Jun 25, 2019
Kind
B2
Abstract

A method for the treatment or prophylaxis of non-inflammatory bowel diseases, diarrhoea-predominant irritable bowel syndrome or other non-specific bowel disorder is disclosed comprising administering to a patient in need of such treatment or prophylaxis an effective amount of balsalazide, or a 4-ASA or 5-ASA compound modified to include a 4-ABA side chain, or a salt or a derivative thereof, or a composition comprising balsalazide the modified compound, or a salt or a derivative thereof together with a suitable carrier. Use of balsalazide, a 4-ASA or 5-ASA compound modified to include a 4-ABA side chain, or a salt or derivative thereof, for the manufacture of a medicament for the treatment or prophylaxis of non-inflammatory bowel diseases, diarrhoea-pre-dominant Irritable Bowel Syndrome or other non-specific bowel disorder is also disclosed.

Claims (12)

1. A method for the treatment or prophylaxis of alternating diarrhoea and constipation type irritable bowel syndrome comprising administering to a patient in need of such treatment or prophylaxis between about 1 gram and about 4 grams of balsalazide or a salt thereof and rifaximin.

2. The method according to claim 1 , wherein the patient is a mammal.

3. The method according to claim 2 , wherein the patient is a human.

4. The method of claim 1 , wherein the disodium salt of balsalazide is administered.

5. The method of claim 1 , wherein about 3 grams of balsalazide is administered.

6. The method of claim 1 , wherein the balsalazide is administered orally.

7. A method for the treatment or prophylaxis of constipation-predominant type irritable bowel syndrome comprising administering to a patient in need of such treatment or prophylaxis between about 1 gram and about 4 grams of balsalazide or a salt thereof and rifaximin.

8. The method according to claim 7 , wherein the patient is a mammal.

9. The method according to claim 8 , wherein the patient is a human.

10. The method of claim 7 , wherein the disodium salt of balsalazide is administered.

11. The method of claim 7 , wherein about 3 grams of balsalazide is administered.

12. The method of claim 7 , wherein the balsalazide is administered orally.

Assignments (11)
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
Reel/Frame 073637/0126 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
Reel/Frame 073654/0242 →
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2025
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED); SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD; SANTARUS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; HUMAX PHARMACEUTICAL S.A.; SOLTA MEDICAL IRELAND LIMITED; BAUSCH & LOMB MEXICO, S.A. DE C.V.; BAUSCH+LOMB OPS B.V.; BAUSCH HEALTH AMERICAS, INC.; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH HOLDCO LIMITED; BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC); BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA); BAUSCH HEALTH US, LLC; BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC.; ICN POLFA RZESZOW SPOLKA AKCYJNA (A/K/A ICN POLFA RZESZOW S.A.); ORAPHARMA, INC.; PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.); SOLTA MEDICAL DUTCH HOLDINGS B.V.; V-BAC HOLDING CORP.; VRX HOLDCO LLC; 1261229 B.C. LTD.; 1530065 B.C. LTD.
Reel/Frame 070778/0199 →
SECURITY AGREEMENT (SECOND LIEN) Recorded Oct 5, 2022
From: BAUSCH HEALTH US, LLC; BAUSCH HEALTH AMERICAS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 061606/0468 →
SECURITY AGREEMENT (FIRST LIEN) Recorded Oct 4, 2022
From: BAUSCH HEALTH US, LLC; BAUSCH HEALTH AMERICAS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 061595/0066 →
SECURITY AGREEMENT Recorded Feb 10, 2022
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 059121/0001 →
SECURITY INTEREST Recorded Jun 8, 2021
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 056811/0814 →
SECURITY INTEREST Recorded Mar 11, 2019
From: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 048556/0758 →
SECURITY INTEREST Recorded Aug 10, 2018
From: BAUSCH & LOMB INCORPORATED; DOW PHARMACEUTICAL SCIENCES, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, LTD; SOLTA MEDICAL, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT PHARMACEUTICALS LUXEMBOURG S.A.R.L.
To: THE BANK OF NEW YORK MELLON, AS COLLATERAL AGENT
Reel/Frame 046616/0301 →
SECURITY INTEREST Recorded Aug 10, 2018
From: BAUSCH & LOMB INCORPORATED; DOW PHARMACEUTICAL SCIENCES, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, LTD; SOLTA MEDICAL, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT PHARMACEUTICALS LUXEMBOURG S.A.R.L.
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 046616/0261 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 29, 2018
From: SHORTIS, NICOLAS PETER
To: SALIX PHARMACEUTICALS, INC.
Reel/Frame 045914/0096 →
Priority Claims (1)
AU 2004900563 · Feb 6, 2004 · national
Continuity (4)
Continuation 14585911 · Dec 30, 2014
Continuation 13742837 · Jan 16, 2013
Continuation 10588558
Related Publication 20180250315A1 · Sep 6, 2018