Oligomer-containing benzamide-based compounds

1. A method of treating gastroparesis or arrhythmia comprising administering to a subject in need thereof an effective amount of a compound having the following structure:

wherein:

R 2 is lower alkyl;

(a) is an integer in the range of from 1 to 4 inclusive;

Y is either O or S;

R 3 is lower alkyl;

R 4 is selected from the group consisting of hydrogen, halo, lower alkoxy, amino, and lower alkylamino;

R 5 is selected from the group consisting of hydrogen, halo, lower alkoxy, amino, and lower alkylamino;

R 6 is selected from the group consisting of hydrogen, halo, lower alkoxy, amino, and lower alkylamino;

X is a stable or releasable linkage; and

POLY is a water-soluble, non-peptidic oligomer having a number of repeating monomers in the range of from 2 to 30,

and pharmaceutically acceptable salts thereof.

2. The method of claim 1 , wherein the compound has the structure:

wherein n is in the range of 2 to 30, and pharmaceutically acceptable salts thereof.

3. The method of claim 1 , wherein the water-soluble, non-peptidic oligomer is a poly(alkylene oxide).

4. The method of claim 3 , wherein the poly(alkylene oxide) is a poly(ethylene oxide).

5. The method of claim 1 , wherein the water-soluble, non-peptidic oligomer has a number of repeating monomers has a number of repeating monomers in the range of from 2 to 10.

6. The method of claim 3 , wherein the poly(alkylene oxide) includes an alkoxy or hydroxyl end-capping moiety.

7. The method of claim 1 , wherein administering comprises administering the compound by a mode of administration selected from the group consisting of parenteral, oral, and transdermal.

8. The method of claim 1 , wherein the therapeutically effective dose of the compound is about 0.001 mg to 1000 mg.

9. The method of claim 1 , wherein said administering comprises administering the compound five times a day, four times a day, three times a day, twice daily, once daily, three times weekly, twice weekly, or once weekly.