Modified antibody regions and uses thereof
The present invention relates to modified Fc regions of antibodies, and uses thereof, such as in antibodies that contain an Fc region of the present invention.
1. An antibody comprising a modified IgG Fc region, wherein the modified IgG Fc region has only a single amino acid substitution relative to a parent IgG Fc region selected from E258F and V427T,
wherein the numbering of positions in the parent IgG Fc region is that of the EU index as in Kabat in the Fc region.
2. The antibody of claim 1 , wherein the amino acid substitution is E258F.
3. The antibody of claim 1 , wherein the amino acid substitution is V427T.
4. The antibody of claim 1 , wherein the parent IgG Fc region comprises a human IgG Fc region.
5. A composition comprising an antibody of claim 1 and a pharmaceutically acceptable carrier, an excipient or a stabilizer.
6. The antibody of claim 1 , wherein the antibody has an increased half life, in comparison with an antibody having the parent IgG Fc region.
7. The composition of claim 5 , wherein the antibody comprises an amount of from about 0.1 to 100 wt. % of the composition.