FERRIC ORGANIC COMPOUNDS, USES THEREOF AND METHODS OF MAKING SAME
The present invention discloses a novel form of ferric organic compounds, including a form of ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. The ferric organic compounds of the present invention can be delivered effectively by oral route with better delivery to treat patients suffering from hyperphosphatemia, metabolic acidosis and other disorders responsive to ferric organic compound therapy.
1 - 81 . (canceled)
82 . A method of treating metabolic acidosis, comprising:
administering a therapeutically effective amount of an orally administrable form of ferric citrate to a subject,
wherein the orally administrable form is prepared from a form of ferric citrate having a BET active surface area greater than 16 sq. m/g.
83 . The method of claim 82 , wherein the BET active surface area ranges from 16 sq. m/g. to 20 sq. m/g.
84 . The method of claim 82 , wherein the orally administrable form is selected from a tablet, a powder, a capsule and a granule.
85 . The method of claim 84 , where in the orally administrable form is a tablet.
86 . The method of claim 82 , wherein the therapeutically effective amount is about 3 to 6 grams per day.
87 . The method of claim 82 , wherein the therapeutically effective amount is selected from 3 grams per day and 4.5 grams per day.
88 . The method of claim 82 , wherein the therapeutically effective amount is 3 grams per day.
89 . The method of claim 82 , wherein the therapeutically effective amount is 6 grams per day.
90 . The method of claim 82 , wherein the subject is a human being.