IP Library › Granted Patent US 10,064,880
Granted Patent B2
US 10,064,880 · App. 15/922,264 · Granted Sep 4, 2018

Silanol based therapeutic payloads

Inventors: Hanh N. Nguyen (Jupiter, FL); Leslie O. Ofori (Jupiter, FL); Jutta Wanner (Palm Beach, FL); Douglas S. Werner (West Palm Beach, FL)
Assignee: BlinkBio, Inc.
A61K31/695A61K47/545A61K47/555C07F7/0836
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Quick Facts
Patent No.
US 10,064,880
App. No.
15/922,264
Granted
Sep 4, 2018
Kind
B2
Abstract

Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.

Claims (7)

1. A silanol drug moiety represented by:

2. The compound of claim 1 , formed by contacting a cell or tissue at a pH of less than about 7 at 37° C. with a silicon drug conjugate represented by:

wherein

Lig is a targeting moiety;

L 1 is a linker moiety;

A is an adaptor moiety or a bond; and

n is 1, 2, 3, 4, 5, 6 or 7.

Continuity (5)
Continuation PCTUS2017036728 · Jun 9, 2017
Provisional Application 62477695 · Mar 28, 2017
Provisional Application 62349274 · Jun 13, 2016
Provisional Application 62347700 · Jun 9, 2016
Related Publication 20180200273A1 · Jul 19, 2018