Kinetin/zeatin topical formulation
View Patent ↗The solubility of kinetin and/or of zeatin is increased when either or both are combined in a formulation that includes a polyoxyalkylene-n-glycerol dicarboxylate component and a fatty acid component. These two components provide a synergistic increase in the solubility of kinetin and/or zeatin that is greater than that which would be expected based on the solubility of kinetin and zeatin in the individual components.
1. A method of treating damage to skin due to aging or sun exposure, said method comprising topically applying to the skin a formulation comprising kinetin and/or zeatin, wherein the kinetin and/or zeatin is contained as part of a liposome and wherein the kinetin and zeatin do not precipitate from the formulation in the presence of water.
2. The method of claim 1 , wherein the formulation comprises a liposome forming agent and a lipophilic skin penetration enhancing agent.
3. The method of claim 2 , wherein the liposome forming agent is a polyoxyalkylene-n-glycerol dicarboxylate component, and wherein the lipophilic skin penetration enhancing agent is a fatty acid component.
4. The formulation of claim 3 , wherein the amounts of the polyoxyalkylene-n-glycerol dicarboxylate component and the fatty acid component are sufficient to provide a synergistic increase in the solubility of the kinetin and/or the zeatin in the formulation.
5. The formulation of claim 3 , wherein the polyoxyalkylene of the polyoxyalkylene-n-glycerol dicarboxylate component is selected from the group consisting of paraformaldehyde, polyethylene glycol, polypropylene glycol, and polytetramethylene glycol.
6. The formulation of claim 3 , wherein the glyceryl dicarboxylate of the polyoxyalkylene-n-glycerol dicarboxylate component is selected from the group consisting of glyceryl dilaurate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl diricinoleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl distearate, glyceryl palmitate lactate, glyceryl stearate citrate, glyceryl stearate lactate, and glyceryl stearate succinate.
7. The method of claim 3 , wherein the fatty acid component comprises one or more fatty acids that are liquid at room temperature or that have a branched or unbranched chain of 12 to 20 carbons.
8. The method of claim 7 , wherein the fatty acid component comprises a mixture of fatty acids.
9. The method of claim 8 , wherein the fatty acid component is a mixture of branched and straight-chain unsaturated C18 fatty acids.
10. The method of claim 9 , wherein the fatty acid component is a mixture of fatty acids having between 12 and 20 carbons.
11. The method of claim 9 , wherein the fatty acid component is a mixture of fatty acids comprising branched and straight chain fatty acids.
12. The method of claim 9 , wherein the fatty acid component is a mixture of fatty acids comprising saturated and unsaturated fatty acids.
13. The method of claim 3 , wherein the polyoxyalkylene-n-glycerol dicarboxylate component is PEG-12 Glycerol dimyristate or PEG-12 Glycerol dioleate.
14. The method of claim 3 , wherein the fatty acid component is isostearic acid.
15. The formulation of claim 3 , wherein the polyoxyalkylene-n-glycerol dicarboxylate component is PEG-12 Glycerol dimyristate or PEG-12 Glycerol dioleate, and the fatty acid component is isostearic acid.
16. The method of claim 1 , wherein the formulation comprises only kinetin.
17. The method of claim 1 , wherein the formulation comprises only zeatin.
18. The method of claim 1 , wherein the formulation comprises both kinetin and zeatin.
19. A method of reducing wrinkles in the skin of a subject, said method comprising topically applying to the skin of the subject a formulation comprising kinetin and/or zeatin, wherein the kinetin and/or zeatin is contained as part of a liposome and wherein the kinetin and zeatin do not precipitate from the formulation in the presence of water.