Use of a bacterium isolated from the genus
The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.
1. An anti-bacterial composition comprising (a) a therapeutically effective amount of the cyclolipoprotein of formula A:
wherein R is selected from the group consisting of:
(i) alkyl groups comprising between 4 and 20 carbon atoms, except nonyl and undecyl groups;
(ii) alkylene groups comprising between 4 and 20 carbon atoms, except undec-4-ylene and tridec-6-ylene groups;
(iii) alkyl groups substituted with an —OH group and comprising between 4 and 20 carbon atoms; and
(iv) alkylene groups substituted with an —OH group and comprising between 4 and 20 carbon atoms, and (b) an effective amount of an adjuvant.
2. The composition according to claim 1 , wherein R is selected from the group consisting of:
(i) alkyl groups comprising between 6 and 14 carbon atoms, except nonyl and undecyl groups;
(ii) alkylene groups comprising between 6 and 14 carbon atoms, except undec-4-ylene and tridec-6-ylene groups;
(iii) alkyl groups substituted with an —OH group and comprising between 6 and 14 carbon atoms; and
(iv) alkylene groups substituted with an —OH group and comprising between 6 and 14 carbon atoms.
3. The composition according to claim 2 , wherein R is selected from the group consisting of the groups: nonylene, nonanol, heptyl, octylene, octyl, decyldiene, decanyl, decanol, decylene, octenol, dodecylene and tridecyltriene.
4. The composition according to claim 1 , wherein the cyclolipoprotein is obtained from a bacterium.
5. The composition according to claim 1 , wherein the composition is a pharmaceutical composition.
6. The composition according to claim 3 , wherein R is nonyl-2-ene.
7. The composition according to claim 3 , wherein R is nonan-2-ol.
8. The composition according to claim 1 , further comprising an organic solvent.
9. The composition according to claim 8 , wherein the organic solvent is glycerol or a glycol, or a mixture of glycerol and the glycol.