Antimicrobial coatings for medical implements and medical devices
The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (R 1 O) 3 Si—R 2 —Z, an organic amine R 9 R 10 R 11 N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R 1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R 2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R 9 , R 10 , and R 11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.
1. A method of coating an implantable medical device, the method comprising:
immersing the implantable medical device in an aqueous composition comprising octadecyldimethyl-(3-trimethoxysilylpropyl) ammonium chloride, 3-chloropropyltrimethoxysilane, triethanolamine and water;
drying the implantable medical device under ambient conditions to produce a coating on the implantable medical device; and
curing the coating on the implantable medical device by heating the implantable medical device at between about 100° C. to about 1000° C. to produce a cured coating on the implantable medical device;
wherein the aqueous composition is of the formulation: 0.75 wt. % octadecyldimethyl-( 3-trimethoxysilylpropyl) ammonium chloride, 0.12 wt. % 3-chloropropyltrimethoxysilane, 0.045 wt. % triethanolamine, and 99.085 wt. % water; and
wherein the cured coating on the implantable medical device exhibits a residual antimicrobial efficacy against at least one of S. epidermidis or E. aerogenes.
2. The method of claim 1 , wherein the implantable medical device comprises a Nitinol stent, an artificial joint, a pin, or a bone screw.
3. The method of claim 1 , wherein the coating on the implantable medical device is cured by heating at about 100° C.
4. The method of claim 1 , wherein the implantable medical device comprises 316 stainless steel or Nitinol and wherein, after the immersing, the implantable medical device is: (a) allowed to dry under ambient conditions, (b) annealed at from about 100° C. to about 1000° C., and (c) sterilized by autoclaving for 20 minutes at 121° C.
5. The method of claim 4 , wherein the cured coating on the implantable medical device exhibits a reduction of S. epidermidis ATCC 12228 of from about 3.14 log 10 to about 3.79 log 10 2 hours after initial inoculation of the coated medical implement with S. epidermidis ATCC 12228.
6. The method of claim 4 , wherein the cured coating on the implantable medical device exhibits a reduction of S. epidermidis ATCC 12228 of from about 3.56 log 10 to about 4.52 log 10 4 hours after initial inoculation of the coated medical implement with S. epidermidis ATCC 12228.
7. The method of claim 4 , wherein the cured coating on the implantable medical device exhibits a reduction of E. aerogenes ATCC 13048 of from about 2.05 log 10 to about 2.94 log 10 2 hours after initial inoculation of the coated medical implement with E. aerogenes ATCC 13048.
8. The method of claim 4 , wherein the cured coating on the implantable medical device exhibits a reduction of E. aerogenes ATCC 13048 of from about 2.06 log 10 to about 2.51 log 10 4 hours after initial inoculation of the coated medical implement with E. aerogenes ATCC 13048.
9. The method of claim 1 , wherein the implantable medical device comprises Nitinol, stainless steel or silicone rubber.
10. The method of claim 1 , wherein the implantable medical device comprises a coronary stent or an indwelling urinary catheter.
11. A method of providing a residual antimicrobial coating on a portion of a surface of a CPAP or BiPAP machine component, the method comprising:
immersing the portion in an aqueous composition comprising octadecyldimethyl-( 3-trimethoxysilylpropyl) ammonium chloride, 3 -chloropropyltrimethoxysilane, triethanolamine and water;
drying the portion under ambient conditions; and
thermally curing the portion at between about 100° C. to about 1000° C. to produce a cured coating on the portion,
wherein the aqueous composition is of the formulation: 0.75 wt. % octadecyldimethyl-( 3-trimethoxysilylpropyl) ammonium chloride, 0.12 wt. % 3 -chloropropyltrimethoxysilane, 0.045 wt. % triethanolamine, and 99.085 wt. % water; and
wherein the portion exhibits a residual antimicrobial efficacy against at least one of S. epidermidis or E. aerogenes.
12. The method of claim 11 , wherein the surface comprises silicone rubber.
13. The method of claim 11 , wherein the CPAP or BiPAP machine component comprises a mask, a mask part, a filter, a hose, a machine part or a humidifier part.
14. The method of claim 13 , wherein the mask comprises a nasal mask, a full face mask, a nasal pillow mask, a nasal prong mask, a hybrid mask, or an oral mask.
15. The method of claim 13 , wherein the mask part comprises a mask kit, a cushion, a pillow, headgear, headgear clips, or a chinstrap.