Hair growth composition and method

1. A composition comprising liquid vesicles suspended within a pharmaceutically acceptable liquid carrier, wherein:

a. the liquid vesicles comprise:

i. minoxidil or a pharmaceutically acceptable salt thereof; and

ii. an C 8 -C 24 alcohol ester of a carboxylic acid; and

b. the pharmaceutically acceptable liquid carrier comprises from about 0.1% to about 60% of one or more solubilizer(s), from about 0.1% to 10% of one or more solubilizing acid(s) or mixtures thereof.

2. The composition of claim 1 , wherein the solubilizer comprises one or more C 1 -C 3 alcohol(s), one or more polyhydric alcohol(s) or mixtures thereof.

3. The composition of claim 1 , wherein the composition comprises from about 0.1% to about 15% of the minoxidil or a pharmaceutically acceptable salt thereof by weight.

4. The composition of claim 3 , wherein the composition comprises from about 0.5% to about 10% of the minoxidil or a pharmaceutically acceptable salt thereof by weight.

5. The composition of claim 1 , wherein the pharmaceutically acceptable carrier comprises minoxidil or a pharmaceutically acceptable salt thereof.

6. The composition of claim 1 , wherein the composition comprises from about 0.1% to about 15%, by weight, of said C 8 -C 24 alcohol ester of a carboxylic acid.

7. The composition of claim 6 , wherein said C 8 -C 24 alcohol ester of a carboxylic acid is an ester of cetyl alcohol.

8. The composition of claim 6 , wherein said C 8 -C 24 alcohol ester of a carboxylic acid is a lactic acid ester.

9. The composition of claim 7 , wherein said C 8 -C 24 alcohol ester of a carboxylic acid is cetyl lactate.

10. The composition of claim 1 wherein the composition further comprises a polyoxyethylene C 4 -C 26 fatty ether.

11. The composition of claim 1 wherein the composition further comprises a polyoxyethylene C 10 -C 18 fatty ether.

12. The composition of claim 10 , wherein the composition comprises from about 0.1% to about 15%, by weight, of the polyoxyethylene C 4 -C 26 fatty ether.

13. The composition of claim 1 wherein the composition further comprises a viscosity modifying agent selected from the group consisting of polyquaternium 37, carboxymethylcellulose, poloxamer 407 or mixtures thereof.

14. The composition of claim 13 wherein the composition has a viscosity of from about 50 cps to about 30000 cps as measure by Brookfield RV at spindle 5, speed 10 RPM.

15. The composition of claim 14 wherein the composition has a viscosity of from about 100 cps to about 15000 cps as measure by Brookfield RV at spindle 5, speed 10 RPM.

16. The composition of claim 14 wherein the composition has a yield stress value of from about 0.01 Pa·s to about 5 Pa·s as measured using a TA Instruments ARES G2 Rheometer in accordance with the method described in the specification hereof.

17. The composition of claim 14 wherein the composition has a shear thinning index of 10 or more.

18. The composition of claim 1 wherein the composition comprises from about 0.1% to about 40% by weight of the one of more C 1 -C 3 alcohols.

19. The composition of claim 18 wherein the one or more C 1 -C 3 alcohols comprises ethanol.

20. The composition of claim 1 wherein the liquid vesicle is a non-phospholipid liquid vesicle.

21. The composition of claim 1 wherein the liquid vesicles have an average diameter of from about 0.05 μm to about 20 μm.

22. A composition comprising:

a. minoxidil or a pharmaceutically acceptable salt thereof;

b. a C 8 -C 24 alcohol ester of a carboxylic acid; and

c. a pharmaceutically acceptable liquid carrier comprising water, one or more C 1 -C 3 alcohol(s), one or more polyhydric alcohol(s) or a mixture thereof

wherein the composition comprises liquid vesicles.

23. A method growing hair in a subject in need of such treatment comprising topically applying the composition of claim 1 to the subject on an area where hair growth is desired.