Use of isoxazoline compounds for treating demodicosis
The present invention relates to methods of treating demodicosis by administering an isoxazoline compound of formula (I)
1. A Method of treating generalized demodicosis in a dog that had been diagnosed with a generalized canine demodicosis comprising administering a composition comprising an effective amount of an isoxazoline compound of Formula (II)
wherein
R 1a , R 1b , R 1c are independently from each other hydrogen, Cl or CF 3 ,
T=
Y=methyl, halomethyl, halogen, CN, NO 2 , or NH 2 —C═S,
Q=X—NR 3 R 4 ;
X=CH 2 , CH(CH 3 ), CH(CN), CO, or CS,
R 3 =hydrogen;
R 4 =hydrogen, ethyl, methoxymethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, methylcarbonyl, ethyl carbonyl, propylcarbonyl, cyclopropylcarbonyl, methoxycarbonyl, methoxymethylcarbonyl, aminocarbonyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, haloethylaminocarbonylmethyl, cyanomethylaminocarbonylmethyl, haloethylaminocarbonylethyl, —CH 2 —C(O)—NH—CH 2 —CF 3 , —CH 2 —C(O)—NH—CH 2 —CH 3 , —CH 2 —CH 2 —CF 3 or —CH 2 —CF 3 ;
or a salt or solvate or N oxide thereof and a pharmaceutically acceptable carrier, wherein the composition is administered once, twice or three times, wherein the treatment results in microscopical cure.
2. The method according to claim 1 comprising a single administration of the isoxazoline compound to the dog.
3. The method according to claim 1 wherein the isoxazoline compound is administered to the dog orally.
4. The method according to claim 1 wherein the isoxazoline compound is administered to the dog topically.
5. The method according to claim 1 wherein the isoxazoline compound is administered to the dog parenterally by injection.
6. The method according to claim 1 , wherein the amount of the isoxazoline compound is effective to reduce the parasite count by 100%.
7. A method of treating generalized demodicosis in a dog that had been diagnosed with a generalized canine demodicosis comprising administering a composition comprising an effective amount of fluralaner or a salt or solvate or N oxide thereof and a pharmaceutically acceptable carrier, wherein the composition is administered once, twice or three times and wherein the treatment results in microscopical cure.
8. The method according to claim 7 comprising a single administration of 10-40 mg/kg bodyweight of fluralaner to the dog.
9. The method according to claim 7 comprising a single administration of the fluralaner to the dog.
10. The method according to claim 7 wherein the fluralaner is administered to the dog orally.
11. The method according to claim 7 wherein the fluralaner is administered to the dog topically.
12. The method according to claim 7 wherein the fluralaner is administered to the dog parenterally by injection.
13. The method according to claim 7 , wherein the amount of the fluralaner is effective to reduce the parasite count by 100%.
14. A method of treating generalized demodicosis in a dog that had been diagnosed with a generalized canine demodicosis comprising administering a composition comprising an effective amount of afoxolaner or a salt or solvate or N oxide thereof and a pharmaceutically acceptable carrier, wherein the composition is administered once, twice or three times and wherein the treatment results in microscopical cure.
15. The method according to claim 14 comprising a double or triple administration of the afoxolaner to the dog.
16. The method according to claim 14 wherein the afoxolaner is administered to the dog orally.
17. The method according to claim 14 wherein the afoxolaner is administered to the dog topically.
18. The method according to claim 14 wherein the afoxolaner is administered to the dog parenterally by injection.
19. A method of treating generalized demodicosis in a dog that had been diagnosed with a generalized canine demodicosis comprising administering a composition comprising an effective amount of sarolaner or a salt or solvate or N oxide thereof and a pharmaceutically acceptable carrier, wherein the composition is administered once, twice or three times and wherein the treatment results in microscopical cure.
20. The method according to claim 19 comprising a double or a triple administration of the sarolaner to the dog.
21. The method according to claim 19 wherein the sarolaner is administered to the dog orally.
22. The method according to claim 19 wherein the sarolaner is administered to the dog topically.
23. The method according to claim 19 wherein the sarolaner is administered to the dog parenterally by injection.
24. A method of treating generalized demodicosis in a dog that had been diagnosed with a generalized canine demodicosis comprising administering a composition comprising an effective amount of lotilaner or a salt or solvate or N oxide thereof and a pharmaceutically acceptable carrier, wherein the composition is administered once, twice or three times and wherein the treatment results in microscopical cure.
25. The method according to claim 24 comprising a double or a triple administration of the lotilaner to the dog.
26. The method according to claim 24 wherein the lotilaner is administered to the dog orally.
27. The method according to claim 24 wherein the lotilaner is administered to the dog topically.
28. The method according to claim 24 wherein the lotilaner is administered to the dog parenterally by injection.