Use of cannabinoids in the treatment of epilepsy
View Patent ↗The present disclosure relates to the use of cannabidiol (CBD) for the reduction of total convulsive seizure frequency in the treatment of “treatment-resistant epilepsy” (TRE). In particular, the disclosure relates to the use of CBD of treating TRE when the TRE is Dravet syndrome; myoclonic absence seizures or febrile infection related epilepsy syndrome (FIRES). The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).
1. A method of treating seizures in a patient with treatment-resistant Lennox-Gastaut syndrome, comprising administering to the patient in need thereof cannabidiol (CBD), wherein the CBD has a purity of at least 98% (w/w) CBD, and wherein the CBD is administered at a dose of 5 mg/kg/day, and then the dose is increased by 2 to 5 mg/kg increments.
2. The method of claim 1 , wherein the administering reduces total convulsive seizure frequency.
3. The method of claim 1 , wherein the dose of the CBD is increased to about 10 mg/kg/day to about 25 mg/kg/day.
4. The method of claim 1 , wherein the dose of the CBD is increased to about 15 mg/kg/day to about 25 mg/kg/day.
5. The method of claim 1 , wherein the dose of the CBD is increased to about 25 mg/kg/day.
6. The method of claim 1 , wherein the dose of the CBD is increased to about 10 mg/kg/day.
7. The method of claim 1 , wherein the dose of the CBD is increased to about 12 mg/kg/day.
8. The method of claim 1 , wherein the dose of the CBD is increased to about 14 mg/kg/day.
9. The method of claim 1 , wherein the dose of the CBD is increased to about 15 mg/kg/day.
10. The method of claim 1 , wherein the dose of the CBD is increased to about 18 mg/kg/day.
11. The method of claim 1 , wherein the dose of the CBD is increased to about 20 mg/kg/day.
12. The method of claim 1 , further comprising administering clobazam to the patient.
13. A method of reducing convulsive seizure frequency in a patient with treatment-resistant Lennox-Gastaut syndrome, comprising administering to the patient in need thereof cannabidiol (CBD), wherein the CBD has a purity of at least 98% (w/w) CBD, wherein the dose of the CBD is 5 mg/kg/day to 25 mg/kg/day.
14. A method of reducing convulsive seizure frequency in a patient with treatment-resistant Dravet syndrome, comprising administering to the patient in need thereof cannabidiol (CBD), wherein the CBD has a purity of at least 98% (w/w) CBD, wherein the dose of the CBD is 5 mg/kg/day to 25 mg/kg/day.
15. The method of claim 1 , wherein the dose of the CBD is increased to about 10 mg/kg/day to about 20 mg/kg/day.
16. A method of treating seizures in a patient with treatment-resistant Dravet syndrome, comprising administering to the patient in need thereof cannabidiol (CBD), wherein the CBD has a purity of at least 98% (w/w) CBD, and wherein the CBD is administered at a dose of 5 mg/kg/day, and then the dose is increased by 2 to 5 mg/kg increments.
17. The method of claim 16 , wherein the administering reduces total convulsive seizure frequency.
18. The method of claim 16 , wherein the dose of the CBD is increased to about 10 mg/kg/day to about 25 mg/kg/day.
19. The method of claim 16 , wherein the dose of the CBD is increased to about 15 mg/kg/day to about 25 mg/kg/day.
20. The method of claim 16 , wherein the dose of the CBD is increased to about 25 mg/kg/day.
21. The method of claim 16 , wherein the dose of the CBD is increased to about 10 mg/kg/day.
22. The method of claim 16 , wherein the dose of the CBD is increased to about 12 mg/kg/day.
23. The method of claim 16 , wherein the dose of the CBD is increased to about 14 mg/kg/day.
24. The method of claim 16 , wherein the dose of the CBD is increased to about 15 mg/kg/day.
25. The method of claim 16 , wherein the dose of the CBD is increased to about 18 mg/kg/day.
26. The method of claim 16 , wherein the dose of the CBD is increased to about 20 mg/kg/day.
27. The method of claim 16 , further comprising administering clobazam to the patient.
28. The method of claim 16 , wherein the dose of the CBD is increased to about 10 mg/kg/day to about 20 mg/kg/day.