Clay-based hemostatic agents
View Patent ↗A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
1. A hemostatic device comprising:
a flexible absorbent substrate comprising cloth, gauze, mesh, or strands; and
a hemostatic material positioned on or in the substrate in a region configured to contact blood from a bleeding wound during use, thereby promoting clotting, the hemostatic material comprising a powder or particulate material that is made using a process involving the use of kaolin or kaolinite;
wherein the substrate initially exists separately from the hemostatic material;
wherein the combination of the substrate and the hemostatic material is sealed in a sterilized packaging and not saturated with a liquid when in the sterilized packaging; and
wherein the hemostatic device is configured so that the hemostatic material does not substantially detach from the substrate before use.
2. The hemostatic device of claim 1 , wherein the process of making the hemostatic material includes heating the kaolin or kaolinite and forming a vitrified or glassy material.
3. The hemostatic device of claim 1 , wherein the process of forming the hemostatic material includes forming a slurry of kaolin, water, and glycerol.
4. The hemostatic device of claim 1 , wherein the hemostatic material is bound to the substrate using a binder.
5. The hemostatic device of claim 4 , wherein the binder is a glycerol.
6. The hemostatic device of claim 1 , further comprising a sulfate.
7. The hemostatic device of claim 1 , wherein the device is subjected to a drying process during manufacturing.
8. The hemostatic device of claim 1 , wherein the substrate includes a permeable pouch to resist detachment of the hemostatic material from the substrate.
9. The hemostatic device of claim 1 , wherein the hemostatic material is incorporated into the substrate to resist detachment of the hemostatic material from the substrate.
10. The hemostatic device of claim 1 , wherein the hemostatic material is trapped within a matrix to resist detachment of the hemostatic material from the substrate.
11. A hemostatic device comprising:
a flexible absorbent substrate; and
a hemostatic material positioned on or in the substrate in a region configured to contact blood from a bleeding wound during use, thereby promoting clotting, the hemostatic material comprising an aluminum silicate;
wherein the substrate initially exists separately from the hemostatic material;
wherein the combination of the substrate and the hemostatic material is not configured to be saturated with a liquid prior to application to the bleeding wound at the time of use; and
wherein the hemostatic device is configured so that the hemostatic material substantially remains on or in the substrate before use.
12. The hemostatic device of claim 11 , wherein the hemostatic material is made at least in part by heating kaolin or kaolinite and forming a vitrified or glassy material.
13. The hemostatic device of claim 11 , wherein the hemostatic material is applied by providing a slurry of kaolin, water, and glycerol.
14. The hemostatic device of claim 11 , wherein the hemostatic material is bound to the substrate using a binder.
15. The hemostatic device of claim 14 , wherein the binder is a glycerol.
16. The hemostatic device of claim 11 , further comprising a sulfate.
17. The hemostatic device of claim 11 , wherein the device is subjected to a drying process during manufacturing.
18. The hemostatic device of claim 11 , wherein the hemostatic device includes a permeable pouch to substantially retain the hemostatic material on the substrate.
19. The hemostatic device of claim 11 , wherein the hemostatic material is incorporated into the substrate to substantially retain the hemostatic material on the substrate.
20. The hemostatic device of claim 11 , wherein the hemostatic material is trapped within a matrix to substantially retain the hemostatic material on the substrate.
21. The hemostatic device of claim 11 , wherein the hemostatic material comprises clay.
22. The hemostatic device of claim 21 , wherein the hemostatic material comprises kaolin or kaolinite.