Analyte signal processing device and methods
Methods and devices for determining a measurement time period, receiving a plurality of signals associated with a monitored analyte level during the determined measurement time period from an analyte sensor, modulating the received plurality of signals to generate a data stream over the measurement time period, and accumulating the generated data stream to determine an analyte signal corresponding to the monitored analyte level associated with the measurement time period are provided. Systems and kits are also described.
1. A method, comprising:
determining a measurement time period using a function of analog to digital conversion time, the measurement time period corresponding to a period of time for obtaining a maximum signal resolution associated with a clock and a signal modulator;
generating one or more clock signals using the clock;
receiving a plurality of analog signals associated with a monitored analyte level during the measurement time period from an analyte sensor;
modulating the received plurality of analog signals using the signal modulator to generate a data stream over the measurement time period based on the received plurality of analog signals by synchronizing each of the received plurality of analog signals to a corresponding one of the one or more clock signals, and filtering one or more signal artifacts from the data stream over the measurement time period, the one or more signal artifacts including a signal transient; and
accumulating the generated data stream to determine an analyte signal corresponding to the monitored analyte level associated with the measurement time period.
2. The method of claim 1 , wherein the data stream includes one or more pulses each associated with a respective one of the one or more clock signals.
3. The method of claim 1 , further comprising transmitting data associated with the monitored analyte level over a communication connection.
4. The method of claim 3 , wherein the communication connection includes a wireless or wired communication connection.
5. The method of claim 1 , wherein the signal modulator includes a sigma-delta modulator.
6. The method of claim 1 , wherein the analyte sensor includes a glucose sensor.
7. The method of claim 1 , further comprising averaging the accumulated generated data stream over the measurement time period.
8. The method of claim 1 , wherein the analyte sensor comprises a plurality of electrodes including a working electrode comprising an analyte-responsive enzyme bonded to a polymer disposed on the working electrode.
9. The method of claim 8 , wherein the analyte-responsive enzyme is chemically bonded to the polymer.
10. The method of claim 8 , wherein the working electrode further comprises a mediator.
11. The method of claim 1 , wherein the analyte sensor comprises a plurality of electrodes including a working electrode comprising a mediator bonded to a polymer disposed on the working electrode.
12. The method of claim 11 , wherein the mediator is chemically bonded to the polymer.
13. The method of claim 11 , wherein the mediator is crosslinked with the polymer.
14. A device, comprising:
a communication component communicatively coupled to an analyte sensor;
a signal modulator;
a clock to generate one or more clock signals; and
one or more processors configured to:
determine a measurement time period using a function of analog to digital conversion time, the measurement time period corresponding to a period of time for obtaining a maximum signal resolution associated with the clock and the signal modulator;
receive a plurality of analog signals associated with a monitored analyte level during the measurement time period from the analyte sensor;
modulate the received plurality of analog signals using the signal modulator to generate a data stream over the measurement time period based on the received plurality of analog signals by synchronizing each of the received plurality of analog signals to a corresponding one of the one or more clock signals, and filtering one or more signal artifacts from the data stream over the measurement time period, the one or more signal artifacts including a signal transient; and
accumulate the generated data stream to determine an analyte signal corresponding to the monitored analyte level associated with the measurement time period.
15. The device of claim 14 , wherein the analyte sensor comprises a plurality of electrodes including a working electrode comprising an analyte-responsive enzyme bonded to a polymer disposed on the working electrode.
16. The device of claim 15 , wherein the analyte-responsive enzyme is chemically bonded to the polymer.
17. The device of claim 15 , wherein the working electrode further comprises a mediator.
18. The device of claim 14 , wherein the analyte sensor comprises a plurality of electrodes including a working electrode comprising a mediator bonded to a polymer disposed on the working electrode.
19. The device of claim 18 , wherein the mediator is chemically bonded to the polymer.
20. The device of claim 18 , wherein the mediator is crosslinked with the polymer.