Radioimaging using low dose isotope
Radioimaging methods, devices and radiopharmaceuticals therefor.
1. A method for identifying a nuclear medicine camera design optimized with respect to functional information gained about a body structure, comprising:
modeling a body-structure, based on its geometry;
modeling anatomical constraints, which limit accessibility to the body structure;
optimizing a camera design using said modeled body-structure and said modeled anatomical constraints; and
performing, with said camera design, radioactive-emission measurements of an in-vivo body-structure that corresponds to said body structure that has been modeled.
2. The method of claim 1 , wherein said camera design includes a plurality of independently moveable detecting units,
wherein said optimizing comprises optimizing position of said independently moveable detecting units.
3. The method of claim 2 , wherein said optimizing comprises conforming said camera design to body contours of said anatomical model.
4. The method of claim 3 , wherein said modeling anatomical constraints comprises identifying body contours from a structural image.
5. The method of claim 4 , wherein said structural image is a CT scan.
6. The method of claim 3 , wherein said optimizing comprises conforming said camera design so that a distance between each of said detecting units and said body contours is less than 2 cm.
7. The method of claim 2 , wherein each of said plurality of independently moveable detecting units is independently moveable along at least one translational axis.
8. The method of claim 5 , wherein said detecting units are moveable to change a separation between said detecting units.
9. The method of claim 4 , wherein said detecting units are arranged in two arcs adapted for viewing a full circumference of said body, from a single position of said camera design.
10. The method of claim 4 , wherein a gantry of said detector camera to which said plurality of detector units are attached, is adapted for rotation.
11. The method of claim 1 , wherein said modeling a body-structure comprises modeling said body-structure using anatomical knowledge regarding one or more of said body-structure size, shape and weight.
12. The method of claim 1 , wherein said optimizing comprising:
providing a plurality of body-structure models; and
selecting said body-structure model from said plurality of models.
13. The method of claim 1 , wherein said modeling of said body-structure comprises modeling said body-structure with one or more target.
14. The method of claim 13 ,
wherein one or more of said one or more targets comprises one or more of:
a hot region of radioactive-emission intensity higher than a background level of radioactive-emission intensity,
a warm region of low-level radioactive-emission intensity, which is above said background level, and
a cold region, of a radioactive-emission intensity lower than said background level.
15. The method of claim 1 , wherein said modeling said anatomical constraints comprises adjusting said modeling based on one or more of age, sex, weight and body type of a patient.
16. The method of claim 1 , comprising:
providing a plurality of nuclear medicine camera designs;
providing a scoring function, by which said camera designs are scored for the modeled body-structure, within the modeled anatomical constraints;
scoring said plurality of camera designs using said scoring function;
selecting a camera design from said plurality of camera designs, based on its score.
17. The method of claim 16 , wherein said scoring comprises:
obtaining representative collections of views of the modeled body-structure, within the modeled anatomical constraints, for different camera designs;
providing a scoring function, by which each representative collection of views, associated with a specific camera design, is scorable with a score that rates information, obtained from the body-structure;
scoring the representative collections of views of the different camera designs; and
selecting a camera design, based on the score of its representative collection of views.
18. The method of claim 1 , comprising:
receiving one or more personal detail of a patient;
adjusting said modelling of said body-structure based on said one or more personal detail.
19. The method of claim 18 , wherein said one or more personal detail of a patient comprises one or more of age, sex, weight, body type, medical records of the patient.
20. The method of claim 1 , wherein said modeling a body structure is using a structural image which includes said in-vivo body-structure.
21. The method of claim 20 , comprising acquiring said structural image, with a structural imager, in tandem with said radioactive-emissions measurements.
22. The method of claim 1 , wherein said performing, comprises oscillatory movement of one or more of said independently moveable detecting units about a detector unit radius, to provide different views for imaging.
23. A nuclear medicine imaging system, comprising:
a radioactive-emission camera, comprising:
a plurality of independently moveable detecting units;
a plurality of motion transfer systems, equal in number to a number of said detecting units, each of the motion transfer systems being in mechanical communication with one of the detecting unit, for moving each said detecting unit; and
a controller for optimizing said radioactive-emission camera configured to:
model a body structure, based on its geometry;
model anatomical constraints, which limit accessibility to the body structure;
optimize a camera design using said modeled body-structure and said modeled anatomical constraints.
24. The nuclear medicine imaging system of claim 23 , comprising a gantry to which said plurality of detecting units are attached, where said motion transfer systems are configured to move each said detecting unit along at least one translational axis, to change a separation between detecting units.
25. An imaging system comprising:
a nuclear imaging system according to claim 23 ;
a structural imager; situated in close proximity to said structural imager; wherein said controller is configured to model said body structure, based on an image acquired by said structural imager.