IP Library Granted Patent US 10,508,268
Granted Patent B2
US 10,508,268 · App. 15/955,923 · Granted Dec 17, 2019

Modified glucosyltransferases for producing branched alpha-glucan polymers

Inventors: Mark S. Payne (Wilmington, DE); Yefim Brun (Wilmington, DE); Richard R. Bott (Kirkland, WA)
Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
C12N9/1051C08B37/0009C12N15/102C12P19/04C12P19/18C12Q1/48C12Y204/01027
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Quick Facts
Patent No.
US 10,508,268
App. No.
15/955,923
Granted
Dec 17, 2019
Kind
B2
Abstract

Glucosyltransferase enzymes are disclosed herein that produce branched alpha-glucan polymer. Also disclosed, for example, are polynucleotides encoding these enzymes, as well as methods of producing branched alpha-glucan polymer.

Claims (12)

1. A glucosyltransferase enzyme comprising an amino acid sequence that is at least 97% identical to: SEQ ID NO:85, SEQ ID NO:89, or SEQ ID NO:93, wherein said glucosyltransferase enzyme lacks the amino acid sequence of SEQ ID NO:78 or SEQ ID NO:80, and wherein said glucosyltransferase enzyme produces a branched alpha-glucan polymer.

2. The glucosyltransferase enzyme of claim 1 , wherein the glucosyltransferase enzyme comprises an amino acid sequence that is at least 98% identical to SEQ ID NO:85, SEQ ID NO:89, or SEQ ID NO:93.

3. A reaction solution comprising water, sucrose, and a glucosyltransferase enzyme according to claim 1 .

4. A method for producing a branched alpha-glucan polymer comprising:

(a) contacting at least water, sucrose, and a glucosyltransferase enzyme according to claim 1 , whereby branched alpha-glucan polymer is produced, and

(b) optionally, isolating the branched alpha-glucan polymer produced in step (a).

5. The glucosyltransferase enzyme of claim 1 , wherein the glucosyltransferase enzyme comprises an amino acid sequence that is at least 97% identical to SEQ ID NO:85.

6. The glucosyltransferase enzyme of claim 1 , wherein the glucosyltransferase enzyme comprises an amino acid sequence that is at least 98% identical to SEQ ID NO:85.

7. The glucosyltransferase enzyme of claim 1 , wherein the glucosyltransferase enzyme comprises an amino acid sequence that is at least 97% identical to SEQ ID NO:89.

8. The glucosyltransferase enzyme of claim 1 , wherein the glucosyltransferase enzyme comprises an amino acid sequence that is at least 98% identical to SEQ ID NO:89.

9. The glucosyltransferase enzyme of claim 1 , wherein the glucosyltransferase enzyme comprises an amino acid sequence that is at least 97% identical to SEQ ID NO:93.

10. The glucosyltransferase enzyme of claim 1 , wherein the glucosyltransferase enzyme comprises an amino acid sequence that is at least 98% identical to SEQ ID NO:93.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 28, 2020
From: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
To: NUTRITION & BIOSCIENCES USA 4, INC.
Reel/Frame 055028/0496 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ENTITY TYPE PREVIOUSLY RECORDED AT REEL: 049879 FRAME: 0043. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 6, 2019
From: E. I. DU PONT DE NEMOURS AND COMPANY
To: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
Reel/Frame 050300/0408 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 26, 2019
From: E. I. DU PONT DE NEMOURS AND COMPANY
To: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
Reel/Frame 049879/0043 →