IP Library Granted Patent US 11,154,896
Granted Patent B2
US 11,154,896 · App. 15/955,973 · Granted Oct 26, 2021

Aerosol generator

Inventors: Harald Schulz (Tuttlingen, DE); Philipp Holzmann (Munich, DE); Dominique Mutschmann (Munich, DE); Michael Hahn (Krailling, DE)
Assignee: PARI Pharma GmbH
B05B17/0646A61M11/005A61M15/00A61M15/0015A61M15/0018A61M15/0085
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Quick Facts
Patent No.
US 11,154,896
App. No.
15/955,973
Granted
Oct 26, 2021
Kind
B2
Abstract

An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane having a first side for being in contact with the fluid and an opposite second side, the membrane having a plurality of through holes penetrating the membrane in an extension direction from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole having along its extension direction a smallest diameter, a larger diameter that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, wherein the ratio of the total length of each through hole in the extension direction to the length of a respective one of said nozzle portions in the extension direction is at least 4, preferably at least 4.5 and most preferred equal to or larger than 5.

Claims (31)

1. A method of manufacturing a vibratable membrane for use in an aerosol generator for generating an aerosol from a fluid, comprising:

providing a vibratable membrane having a first side for contact with the fluid and an opposite second side, and

providing the membrane with a plurality of through holes penetrating the membrane from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole having a nozzle portion, wherein

a ratio of a total length of each through hole to a length of the nozzle portion is at least 4 , and wherein

the through holes are formed using a laser drilling process including at least two laser drilling stages for forming each of the through holes.

2. The method of claim 1 , wherein the nozzle portion is formed to be substantially cylindrical or conical.

3. The method of claim 1 , wherein the through holes are formed to have two or more portions and the nozzle portion.

4. The method of claim 1 , wherein one end of the nozzle portion is formed to terminate flush with the second side.

5. The method of claim 1 , wherein the total length of the through holes is at least 50 μm.

6. The method of claim 1 , wherein the total length of the through holes is at least 70 μm.

7. The method of claim 1 , wherein the total length of the through holes is at least 90 μm.

8. The method of claim 1 , wherein the at least two laser drilling stages have different process parameters.

9. The method of claim 8 , wherein the ratio of the total length of each through hole to the length of the nozzle portion is in a range of 4 to 10.

10. The method of claim 1 , wherein the length of the nozzle portion is less than 25 μm.

11. The method of claim 1 , wherein the length of the nozzle portion is less than 20 μm.

12. The method of claim 1 , wherein the length of the nozzle portion is less than 15 μm.

13. A method of manufacturing a vibratable membrane for use in an aerosol generator for generating an aerosol from a fluid, comprising:

providing a vibratable membrane having a first side for contact with the fluid and an opposite second side, and

providing the membrane with a plurality of through holes penetrating the membrane from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole having a first portion, a second portion and a nozzle portion, wherein

a ratio of a total length of each through hole to a length of the nozzle portion is at least 4 , and wherein

the through holes are formed using a laser drilling process including a first laser drilling stage for forming the first portion of each through hole, a second laser drilling stage for forming the second portion of each through hole and a third laser drilling stage for forming the nozzle portion of each through hole.

14. The method of claim 13 , wherein the nozzle portion is formed to be substantially cylindrical or conical.

15. The method of claim 13 , wherein one end of the nozzle portion is formed to terminate flush with the second side.

16. The method of claim 13 , wherein the total length of the through holes is at least 50 μm.

17. The method of claim 13 , wherein the total length of the through holes is at least 70 μm.

18. The method of claim 13 , wherein the total length of the through holes is at least 90 μm.

19. The method of claim 13 , wherein the first, second and third laser drilling stages have different process parameters.

20. The method of claim 19 , wherein the ratio of the total length of each through hole to the length of the nozzle portion is in a range of 4 to 10.

21. The method of claim 13 , wherein the length of the nozzle portion is less than 25 μm.

22. The method of claim 13 , wherein the length of the nozzle portion is less than 20 μm.

23. The method of claim 13 , wherein the length of the nozzle portion is less than 15 μm.

Assignments (3)
PATENT SECURITY AGREEMENT Recorded Oct 20, 2022
From: INSMED INCORPORATED
To: BIOPHARMA CREDIT PLC
Reel/Frame 061735/0875 →
SECOND LIEN PATENT SECURITY AGREEMENT Recorded Oct 19, 2022
From: INSMED INCORPORATED
To: ORBIMED ROYALTY & CREDIT OPPORTUNITIES IV, LP
Reel/Frame 061727/0039 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 23, 2018
From: SCHULZ, HARALD; HOLZMANN, PHILIPP; MUTSCHMANN, DOMINIQUE; HAHN, MICHAEL
To: PARI PHARMA GMBH
Reel/Frame 045608/0355 →