Method for Treatment and Prevention of Biofilm Formation During Breast Augmentation Procedures
The present disclosure provides methods and compositions for the treatment and prevention of infections and biofilm prevention during breast augmentation procedures. The present disclosure also provides methods and compositions for the prevention of anaplastic large-cell lymphoma following breast augmentation procedures. The present methods comprise providing a breast implant pocket at a surgical site in a patient and irrigating the pocket with a solution of hypochlorous acid. In some embodiments, the methods further comprise treating a breast implant with a solution of hypochlorous acid for a period of time prior to a breast augmentation procedure. Further provided are hypochlorous acid solutions useful in the aforementioned methods.
1 . A method of treating or preventing bacterial biofilm formation during a breast augmentation surgical procedure comprising:
providing a breast implant pocket at a surgical site in a patient and
irrigating the pocket with a solution of hypochlorous acid.
2 . The method of claim 1 , wherein the method further comprises soaking a breast implant in a hypochlorous acid solution prior to inserting the implant into the pocket.
3 . The method of claim 2 , further comprising irrigating the surgical site with a solution of hypochlorous acid after inserting the implant into the pocket.
4 . The method of claim 1 , wherein the hypochlorous acid has a concentration of about 0.01% to about 0.1% in the solution.
5 . The method of claim 4 , wherein the concentration is about 0.01% to about 0.075%.
6 . The method of claim 4 , wherein the concentration is about 0.02% to about 0.05%.
7 . The method of claim 4 , wherein the concentration is about 0.02% to about 0.03%.
8 . (canceled)
9 . The method of claim 1 , wherein the bacterial biofilm is a Ralstonia pickettii biofilm.
10 . A method of treating or preventing a Ralstonia Pickettii infection during a breast augmentation procedure comprising:
providing a breast implant pocket at a surgical site in a patient and irrigating the pocket with a solution of hypochlorous acid.
11 . The method of claim 10 , wherein the method further comprises soaking a breast implant in a hypochlorous acid solution prior to inserting the implant into the pocket.
12 . The method of claim 10 , further comprising irrigating the surgical site with a solution of hypochlorous acid after inserting the implant into the pocket.
13 . The method of claim 10 , wherein the hypochlorous acid has a concentration of about 0.01% to about 0.1% in the solution.
14 . The method of claim 13 , wherein the concentration is about 0.01% to about 0.075%.
15 . The method of claim 13 , wherein the concentration is about 0.02% to about 0.05%.
16 . The method of claim 13 , wherein the concentration is about 0.02% to about 0.03%.
17 . (canceled)
18 . A method of preventing the occurrence of anaplastic large-cell lymphoma following a breast augmentation procedure comprising:
providing a breast implant pocket at a surgical site in a patient and
irrigating the pocket with a solution of hypochlorous acid.
19 . The method of claim 18 , wherein the method further comprises soaking a breast implant in a hypochlorous acid solution prior to inserting the implant into the pocket.
20 . The method of claim 19 , further comprising irrigating the surgical site with a solution of hypochlorous acid after inserting the implant into the pocket.
21 . The method of claim 18 , wherein the hypochlorous acid has a concentration of about 0.01% to about 0.1% in the solution.
22 . The method of claim 21 , wherein the concentration is about 0.01% to about 0.075%.
23 - 34 . (canceled)