Neridronic acid for treating complex regional pain syndrome
Oral dosage forms of osteoclast inhibitors, such as neridronic acid, in an acid form or a salt form can be used to treat or alleviate pain or related conditions, such as allodynia associated with complex regional pain syndrome.
1. A method of treating severe pain associated with complex regional pain syndrome, comprising administering a parenteral dose of 5 mg to 500 mg of neridronic acid, in a salt form or an acid form, to a human being suffering from severe pain associated with complex regional pain syndrome, wherein the human being has a pain score of at least about 7 on the 0-10 numeric rating scale.
2. The method of claim 1 , wherein the parenteral dose is administered in divided doses of about 10 mg to about 150 mg of the neridronic acid.
3. The method of claim 1 , wherein the human being is suffering from complex regional pain syndrome type I.
4. The method of claim 1 , wherein the human being is suffering from complex regional pain syndrome type II.
5. A method of treating hyperalgesia associated with complex regional pain syndrome, comprising administering a parenteral dose of 5 mg to 500 mg of neridronic acid, in a salt form or an acid form, to a human being suffering from hyperalgesia associated with complex regional pain syndrome.
6. The method of claim 5 , wherein the parenteral dose is administered in divided doses of about 10 mg to about 150 mg of the neridronic acid.
7. The method of claim 5 , wherein the human being is suffering from complex regional pain syndrome type I.
8. The method of claim 5 , wherein the human being is suffering from complex regional pain syndrome type II.
9. A method of treating allodynia associated with complex regional pain syndrome, comprising administering a parenteral dose of 5 mg to 500 mg of neridronic acid, in a salt form or an acid form, to a human being suffering from allodynia associated with complex regional pain syndrome.
10. The method of claim 9 , wherein the parenteral dose is administered in divided doses of about 10 mg to about 150 mg of the neridronic acid.
11. The method of claim 9 , wherein the human being is suffering from complex regional pain syndrome type I.
12. The method of claim 9 , wherein the human being is suffering from complex regional pain syndrome type II.
13. A method of treating edema associated with complex regional pain syndrome, comprising administering a parenteral dose of 5 mg to 500 mg of neridronic acid, in a salt form or an acid form, to a human being suffering from edema associated with complex regional pain syndrome.
14. The method of claim 13 , wherein the parenteral dose is administered in divided doses of about 10 mg to about 150 mg of the neridronic acid.
15. The method of claim 13 , wherein the human being is suffering from complex regional pain syndrome type I.
16. The method of claim 13 , wherein the human being is suffering from complex regional pain syndrome type II.