IP Library › Patent Application 15968520
Patent Application
App. No. 15/968,520

COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION

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Quick Facts
Patent No.
US None
App. No.
15/968,520
Abstract

The present embodiments provide methods, compounds, and compositions for treating, preventing, or ameliorating a disease associated with excess growth hormone using antisense compounds or oligonucleotides targeted to growth hormone receptor (GHR).

Claims (22)

1 .- 192 . (canceled)

193 . A compound consisting of a conjugate group and a modified oligonucleotide according to the following formula:

194 . A composition comprising the compound of claim 193 or salt thereof and at least one of a pharmaceutically acceptable carrier or diluent.

195 . A prodrug comprising the compound of claim 193 .

196 . (canceled)

197 . (canceled)

198 . A method comprising administering to an animal the compound claim 193 .

199 . The method of claim 198 , wherein the animal is a human.

200 . A method of treating a disease associated with excess growth hormone in a human comprising administering to the human a therapeutically effective amount of the compound of claim 193 thereby treating the disease associated with excess growth hormone.

201 . The method of claim 200 , wherein the disease associated with excess growth hormone is acromegaly.

202 . The method of claim 200 , wherein the treatment reduces IGF-1 levels.

203 . A method of preventing a disease associated with excess growth hormone in a human comprising administering to the human a therapeutically effective amount of a compound of claim 193 thereby preventing the disease associated with excess growth hormone.

204 . The method of claim 203 , wherein the disease associated with excess growth hormone is acromegaly.

205 . The method of claim 200 , comprising co-administering the compound and a second agent.

206 . The method of claim 205 , wherein the compound or composition and the second agent are administered concomitantly.

207 . A method of reducing growth hormone receptor (GHR) levels in a human comprising administering to the human a therapeutically effective amount of the compound of claim 193 , thereby reducing GHR levels in the human.

208 . The method of claim 207 , wherein the human has a disease associated with excess growth hormone.

209 . The method of claim 207 , wherein the disease associated with excess growth hormone is acromegaly.

210 . The method of claim 209 , comprising co-administering the compound and a second agent.

211 . The method of claim 210 , wherein the compound and the second agent are administered concomitantly.

212 . (canceled)

213 . (canceled)