IP Library › Granted Patent US 11,041,011
Granted Patent B2
US 11,041,011 · App. 15/969,211 · Granted Jun 22, 2021

Human alpha fetoprotein-specific murine T cell receptors and uses thereof

Inventors: Yukai He (Martinez, GA); Wei Zhu (Augusta, GA); Esteban Celis (Augusta, GA); Yibing Peng (Augusta, GA); Lan Wang (Augusta, GA)
Assignees: Augusta University Research Institute, Inc.; National Institutes of Health (NIH); U.S. Dept. of Health And Human Services (DHHS); U.S. Government NIH Division of Extramural Inventionsl and Technology Resources (DEITR)
C07K14/7051A61K35/17A61P35/00A61K38/00C07K16/462
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Quick Facts
Patent No.
US 11,041,011
App. No.
15/969,211
Granted
Jun 22, 2021
Kind
B2
Abstract

T cell receptors that specifically recognize hAFP 158 and methods of their use are provided.

Claims (5)

1. A recombinant T cell receptor (TCR) comprising:

a) a Vα domain comprising an amino acid sequence set forth SEQ ID NO:16; and

b) a Vβ domain comprising an amino acid sequence set forth in SEQ ID NO:24.

2. The recombinant T cell receptor of claim 1 , wherein the TCR is a humanized TCR.

3. A recombinant T cell receptor (TCR) polypeptide or protein comprising at least one Vα chain polypeptide and at least one Vβ chain polypeptide, wherein the Vα chain polypeptide comprises an amino acid sequence set forth in SEQ ID NO: 3, and the Vβ chain polypeptide comprises an amino acid sequence set forth in SEQ ID NO: 11, wherein the TCR specifically binds to an HLA-A2/hAFP 158 (SEQ ID NO: 1) complex.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 28, 2018
From: HE, YUKAI; ZHU, WEI; CELIS, ESTEBAN; PENG, YIBING; WANG, LAN
To: AUGUSTA UNIVERSITY
Reel/Frame 046224/0248 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 28, 2018
From: AUGUSTA UNIVERSITY
To: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
Reel/Frame 046224/0567 →
CONFIRMATORY LICENSE Recorded May 25, 2018
From: AUGUSTA UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 046245/0984 →
Continuity (4)
Provisional Application 62505406 · May 12, 2017
Provisional Application 62609614 · Dec 22, 2017
Provisional Application 62625051 · Feb 1, 2018
Related Publication 20180327473A1 · Nov 15, 2018