PAIN RELIEF COMPOSITIONS, MANUFACTURE AND USES
The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
1 . A composition comprising:
i) 0.2-30% by weight of a capsaicinoid, and
ii) 50-95% by weight of an analgesic agent comprising a) a topical salicylate and b) a TRPM8 agonist or a TRPV3 agonist, capable of solubilizing said capsaicinoid,
wherein said composition comprises an amount of capsaicinoid sufficient to decrease the density of functional nociceptive nerve fibers when said composition is applied topically to a mammal, and said composition comprises an amount of analgesic agent sufficient to eliminate or reduce the burning or stinging sensation or erythema created by the topical administration of the capsaicinoid to a mammal.