Protein kinase inhibitors
A compound of formula (I), wherein R 3 , R 4 , G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (1) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.
1. A compound of formula (Ia)
wherein
Z is CH;
A is a pyrazolyl ring;
R 1 is H;
R 2 is C 1-7 alkyl;
B is phenyl;
R 3 and R 4 are halogen;
M is —NHSO 2 R 8 ;
R 8 is C 1-7 alkyl or C 3-7 cycloalkyl;
or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 , wherein R 3 is fluoro.
3. The compound according to claim 1 , wherein R 4 is fluoro.
4. The compound according to claim 1 , wherein R 2 is methyl.
5. The compound according to claim 1 , wherein R 8 is cyclopropyl.
6. The compound according claim 1 , which is
N-(2′,4′-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-biphenyl-3-yl)methanesulfonamide;
N-(2′,4′-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-biphenyl-3-yl)ethanesulfonamide;
N-(2′,4′-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-biphenyl-3-yl)propane-2-sulfonamide;
N-(2′,4′-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-biphenyl-3-yl)cyclopropanesulfonamide;
N-(2′,4′-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-biphenyl-3-yl)cyclopentanesulfonamide;
N-(2′,6′-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1′-biphenyl]-3-yl)methanesulfonamide;
N-(2′,6′-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1′-biphenyl]-3-yl)ethanesulfonamide;
N-(2′,4′-difluoro-5-(5-(1-methyl-1H-pyrazol-3-yl)-1H-benzo[d]imidazol-1-yl)-[1,1′-biphenyl]-3-yl)methanesulfonamide;
N-(2′,4′-difluoro-5-(5-(1-isopropyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1, 1′-biphenyl]-3-yl)cyclopropanesulfonamide;
N-(2′,4′-difluoro-5-(5-(1-isopropyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1′-biphenyl]-3-yl)methanesulfonamide;
N-(2′,4′-difluoro-5-(5-(1-isopropyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1′-biphenyl]-3-yl)ethanesulfonamide;
N-(2′,5′-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1′-biphenyl]-3-yl)ethanesulfonamide; or
or a pharmaceutically acceptable salt thereof.