Zwitterion-functionalized multicomponent copolymers and associated polymer blends and membranes
Multicomponent copolymers including two or more types of repeat units is presented. In one example, the multicomponent copolymer includes at least one repeat unit AC having a structure (I), at least one repeat unit DC having a structure (II), and at least one repeat unit BC having a structure (III) or (V). The multicomponent copolymer may be cross-linked via a cross-linking agent. A polymer blend including the multicomponent copolymer or a cross-linked copolymer and a second polymer is also provided. The multicomponent copolymer may be a random or a block copolymer. The structural units of the multicomponent copolymers provide improved, tunable properties, such as improved biocompatibility and hydrophilicity, protein fouling, and mechanical properties, to the copolymers and/or the membranes fabricated from the copolymers.
1. A multicomponent copolymer comprising:
at least one repeat unit AC having a structure (I), at least one repeat unit DC having a structure (II), and at least one repeat unit BC having a structure (III):
wherein “a”, “b” and “c” are independently at each occurrence 1, 2, 3, or 4;
“k” ranges from 0 to 10;
“o”, “p”, “m” and “n” are each, independently, 0 or 1;
R 1 , R 2 and R 5 are independently at each occurrence a hydrogen atom, a halogen atom, a nitro group, a C 3 -C 12 aliphatic radical, a C 3 -C 12 cycloaliphatic radical, or a C 3 -C 12 aromatic radical;
R 3 and Y are each, independently, a hydrogen atom, a C 1 -C 12 aliphatic radical, a C 3 -C 12 cycloaliphatic radical, or a C 3 -C 12 aromatic radical;
R 4 is a bond, a C 1 -C 12 aliphatic radical, a C 3 -C 12 cycloaliphatic radical, or a C 3 -C 12 aromatic radical, and
wherein the copolymer has a formula [(AC) P*S -(DC) Z*S -(BC)R] wherein S is a mole fraction of a total piperazine content, P*S is a mole fraction of a piperazine content of the repeat units AC, Z*S is a mole fraction of a zwitterion content of the repeat units DC, and R is a mole fraction of the repeat units BC in the copolymer, and wherein P+Z=1, S+R=1, wherein P*S ranges from about 0.01 to about 0.4 and Z*S ranges from about 0.10 to about 0.6.
2. The copolymer of claim 1 , wherein the copolymer is a random copolymer comprising randomly distributed sequences of each of the at least one repeat unit AC, BC and DC.
3. The copolymer of claim 1 , wherein Z*S ranges from about 0.3 to about 0.5.
4. The copolymer of claim 1 , wherein P*S ranges from about 0.01 to about 0.15.
5. The copolymer of claim 1 , wherein R ranges from about 0.4 to about 0.75.
6. The copolymer of claim 1 , wherein R ranges from about 0.5 to about 0.6.
7. The copolymer of claim 1 , wherein the weight average molecular weight (M w ) of the copolymer ranges from about 10,000 g/mol to about 90,000 g/mol.
8. The copolymer of claim 1 , wherein the weight average molecular weight (Mw) of the copolymer ranges from about 40,000 g/mol to about 75,000 g/mol.
9. The copolymer of claim 1 , the at least one repeat unit AC having a structure (I) wherein “k” ranges from 1 to 4; “m” and “n” are both 0; R 1 , R 2 , R 3 and R 5 are independently at each occurrence a hydrogen atom or a C 1 -C 4 aliphatic radical.
10. The copolymer of claim 1 , the at least one repeat unit BC having a structure (III) wherein “m” and “n” are both 0; R 2 , R 5 , R 6 and Y′ are independently at each occurrence a hydrogen atom or a C 1 -C 4 aliphatic radical.
11. A membrane comprising:
a multicomponent copolymer comprising at least one repeat unit AC having a structure (I), at least one repeat unit DC comprising a structural unit having a structure (II), and at least one repeat unit BC comprising a structural unit having a structure (III):
wherein “a”, “b” and “c” are independently at each occurrence 1, 2, 3, or 4;
“k” ranges from 0 to 10;
“o”, “p”, “m” and “n” are each, independently, 0 or 1;
R 1 , R 2 and R 5 are independently at each occurrence a hydrogen atom, a halogen atom, a nitro group, a C 3 -C 12 aliphatic radical, a C 3 -C 12 cycloaliphatic radical, or a C 3 -C 12 aromatic radical;
R 3 and Y are each, independently, a hydrogen atom, a C 1 -C 12 aliphatic radical, a C 3 -C 12 cycloaliphatic radical, or a C 3 -C 12 aromatic radical;
R 4 is a bond, a C 1 -C 12 aliphatic radical, a C 3 -C 12 cycloaliphatic radical, or a C 3 -C 12 aromatic radical, and
wherein the copolymer has a formula [(AC) P*S -(DC) Z*S -(BC)R] wherein S is a mole fraction of a total piperazine content, P*S is a mole fraction of a piperazine content of the repeat units AC, Z*S is a mole fraction of a zwitterion content of the repeat units DC, and R is a mole fraction of the repeat units BC in the copolymer, and wherein P+Z=1, S+R=1 wherein P*S ranges from about 0.01 to about 0.4 and Z*S ranges from about 0.10 to about 0.6.
12. An apparatus comprising a hollow fiber module comprising a plurality of membranes of claim 11 , wherein each membrane is a hollow fiber membrane.
13. A crosslinked polymer, comprising:
the copolymer of claim 11 , wherein the copolymer is crosslinked through one or more piperazine groups of the at least one repeat unit AC with a crosslinking agent.