IBAT inhibitors for the treatment of liver diseases
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
1. A method for the treatment of non-alcoholic fatty liver disease (NAFLD), comprising orally administering to a subject in need of such treatment a therapeutically effective amount of an IBAT inhibitor, wherein the IBAT inhibitor is 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N—{(R)-1′-phenyl-1′-[N′-(carboxymethyl)carbamoyl]methyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepine, or a pharmaceutically acceptable salt thereof.
2. The method according to claim 1 , wherein treatment of non-alcoholic fatty liver disease (NAFLD) decreases the level of serum bile acids in the subject.
3. The method according to claim 1 , wherein treatment of non-alcoholic fatty liver disease (NAFLD) decreases the level of liver bile acids in the subject.
4. The method according to claim 1 , wherein the subject has liver fibrosis caused by the non-alcoholic fatty liver disease (NAFLD).
5. The method according to claim 1 , wherein the subject has hepatic cirrhosis caused by the non-alcoholic fatty liver disease (NAFLD).
6. The method according to claim 1 , wherein the subject has pruritus as a symptom of non-alcoholic fatty liver disease (NAFLD).
7. The method according to claim 1 , wherein the subject has liver fibrosis as a comorbidity.
8. The method according to claim 1 , wherein the subject has hepatic cirrhosis as a comorbidity.