Natural and synthetic andrographolides compounds for the treatment of skeletal muscular dystrophies
Andrographolide 70 mg orally twice per day maintains normal health and body function in pediatric patients with Duchenne muscular dystrophy (DMD) and Becker's muscular dystrophy (BMD), and treats DMD/BMD.
1. A method comprising: diagnosing Duchenne or Becker's muscular dystrophy in a human, and then providing to the human an oral formulation of andrographolide, said oral formulation including an amount of ardrographolide effective to maintain healthy function in the human or treat at least one symptom of Duchenne or Becker's muscular dystrophy.
2. The method of claim 1 , wherein the oral formulation includes an amount of andrographolide effective to treat at least one symptom of Duchenne or Becker's muscular dystrophy.
3. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to improve quality of life.
4. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to improve quality of sleep.
5. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to reduce DMD/BMD associated pain.
6. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to reduce DMD/BMD associated perception of cold.
7. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to improve the ability to walk or move.
8. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to improve the ability to play or run.
9. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to improve the ability to jump.
10. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to improve muscular coordination.
11. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to improve muscular force.
12. The method of claim 2 , wherein the oral formulation includes an amount of andrographolide effective to improve mood.
13. The method of claim 1 , wherein the oral formulation includes an amount of andrographolide effective to maintain healthy function in the human.
14. The method of claim 1 , where said human is not more than 21 years of age.
15. The method of claim 1 , where said amount of andrographolide is about 140 mg a day.
16. The method of claim 15 , wherein said andrographolide is administered as two 70 mg doses per day.
17. The method of claim 1 , where said amount andrographolide is about 0.8 to about 5.5 mg/kg of patient body weight a day.
18. The method of claim 17 , where said andrographolide is administered as two doses per day, each dose comprising about 0.4 to about 2.75 mg/kg of patient body weight per day.