Cyclooxygenase Inhibitor and Calcium Channel Antagonist Compositions and Methods for Use in Urological Procedures
Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.
1 .- 11 . (canceled)
12 . A method of inhibiting pain/inflammation and spasm in the urinary tract, comprising:
delivering to the urinary tract a composition including a combination of ketoprofen and a calcium channel antagonist in a carrier, each of the ketoprofen and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.
13 . The method of claim 12 , wherein the composition is delivered periprocedurally to the urinary tract during a urological diagnostic, interventional, surgical and other medical procedure.
14 . The method of claim 13 , wherein the composition is periprocedurally delivered during a cystoscopic procedure.
15 . The method of claim 13 , wherein the composition is periprocedurally delivered during a ureteroscopic procedure.
16 . The method of claim 13 , wherein the composition is periprocedurally delivered during a procedure to remove, fragment or dislodge a kidney or bladder stone.
17 . The method of claim 13 , wherein the composition is periprocedurally delivered during a procedure that causes thermal injury to urinary tract tissue.
18 . The method of claim 17 , wherein the composition is periprocedurally delivered during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure.
19 . The method of claim 13 , wherein the composition is periprocedurally delivered during a transurethral resection of a prostate.
20 . The method of claim 12 , wherein the calcium channel antagonist in the composition comprises nifedipine.
21 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a diagnostic, interventional, surgical or other medical urological procedure, comprising:
periprocedurally delivering to the urinary tract during a urological procedure a composition including a combination of ketoprofen and nifedipine in a carrier, each of the ketoprofen and the nifedipine included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.
22 . The method of claim 21 , wherein the composition is during a cystoscopic procedure.
23 . The method of claim 21 , wherein the composition is periprocedurally delivered during a ureteroscopic procedure.
24 . The method of claim 21 , wherein the composition is periprocedurally delivered during a procedure to remove, fragment or dislodge a kidney or bladder stone.
25 . The method of claim 21 , wherein the composition is periprocedurally delivered during a procedure that causes thermal injury to urinary tract tissue.
26 . The method of claim 25 , wherein the composition is periprocedurally delivered during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure.
27 . The method of claim 21 , wherein the composition is periprocedurally delivered during a transurethral resection of a prostate.
28 . The method of claim 21 , wherein the composition is periprocedurally delivered transrectally or transperitoneally to the prostate.
29 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a urological procedure, comprising:
periprocedurally delivering to the urinary tract during a ureteroscopic procedure a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.
30 . The method of claim 29 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor.
31 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a urological procedure, comprising:
periprocedurally delivering to the urinary tract during a procedure to remove, fragment or dislodge a kidney or bladder stone a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.
32 . The method of claim 31 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor.
33 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a urological procedure, comprising:
periprocedurally delivering to the urinary tract during a procedure that causes thermal injury to urinary tract tissue a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.
34 . The method of claim 33 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor.
35 . The method of claim 34 , wherein the composition is delivered periprocedurally to the urologic structure during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure.
36 . A method of inhibiting pain/inflammation and spasm during a urological procedure, comprising:
periprocedurally delivering transrectally or transperitoneally to the prostate a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm.
37 . The method of claim 36 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor.
38 . A method of inhibiting pain, inflammation and/or spasm in the urinary tract during a urological procedure, comprising:
periprocedurally delivering to the urinary tract during a ureteroscopic procedure a composition including a combination of a plurality of agents that inhibit pain/inflammation and/or spasm in a carrier, each agent included in a therapeutically effective amount such that the combination inhibits pain/inflammation and/or spasm in the urinary tract.
39 . A method of inhibiting pain, inflammation and/or spasm in the urinary tract during a urological procedure, comprising:
periprocedurally delivering to the urinary tract during a procedure to remove, fragment or dislodge a kidney or bladder stone a composition including a combination of a plurality of agents that inhibit pain/inflammation and/or spasm in a carrier, each agent included in a therapeutically effective amount such that the combination inhibits pain/inflammation and/or spasm in the urinary tract.
40 . A method of inhibiting pain, inflammation and/or spasm in the urinary tract during a urological procedure, comprising:
periprocedurally delivering to the urinary tract during a procedure that causes thermal injury to urinary tract tissue a composition including a combination of a plurality of agents that inhibit pain/inflammation and/or spasm in a carrier, each agent included in a therapeutically effective amount such that the combination inhibits pain/inflammation and/or spasm in the urinary tract.
41 . The method of claim 40 , wherein the composition is delivered periprocedurally to the urologic structure during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure.
42 . A method of inhibiting pain, inflammation and/or spasm during a urological procedure, comprising:
periprocedurally delivering transrectally or transperitoneally to the prostate a composition including a combination of a plurality of agents that inhibit pain/inflammation and/or spasm in a carrier, each agent included in a therapeutically effective amount such that the combination inhibits pain/inflammation and/or spasm.