Method and system for estimating patient recovery time utilizing neuromuscular transmission measurements

1. A method to estimate recovery time of a patient from neuromuscular block (NMB), comprising:

applying a first series of stimulations including a first, a second, a third and a fourth stimulation, to a nerve of the patient at a first measurement time;

measuring a first muscle twitch in response to the first stimulation and a second muscle twitch in response to the second stimulation in response to the first series of stimulations;

calculating a first train-of-two (TO2) ratio based on the first muscle twitch and the second muscle twitch at the first measurement time;

applying a second series of stimulations including a first, a second, a third and a fourth stimulation, to the nerve of the patient at a second measurement time after the first measurement time;

measuring a first muscle twitch in response to the first stimulation and a second muscle twitch in response to the second stimulation in response to the second series of stimulations;

calculating a second train-of-two (TO2) ratio based on the first muscle twitch and the second muscle twitch at the second measurement time;

determining a predicted neuromuscular blocking trend curve based on the calculated first and second train-of-two (TO2) ratios;

utilizing a controller configured to determine a predicted neuromuscular blocking trend curve based on the calculated first and second train-of-two (TO2) ratios;

utilizing the controller also configured to estimate a recovery time based on the predicted blocking trend curve after the second measurement time; and

providing the estimated recovery time.

2. The method of claim 1 wherein the first series of stimulations and the second series of stimulations are train-of-four (TOF) stimulations.

3. The method of claim 2 wherein the first muscle twitch, the second muscle twitch, a third muscle twitch and a fourth muscle twitch are measured for each of the first and second TOF stimulations.

4. The method of claim 3 further comprising the steps of:

calculating a first train-of-four (TOF) ratio based on the first muscle twitch and the fourth muscle twitch at the first measurement time;

calculating a second train-of-four (TOF) ratio based on the first muscle twitch and the fourth muscle twitch at the second measurement time;

determining a predicted slope for the TOF ratio over time;

applying the predicted slope to the calculated first and second TOF ratios to create the predicted neuromuscular blocking trend curve; and

predicting the estimated recovery time based on the predicted neuromuscular blocking trend curve.

5. The method of claim 4 wherein the predicted neuromuscular blocking trend curve relates the TOF ratio to time.

6. The method of claim 5 wherein the predicted recovery time occurs when the TOF ratio of the predicted neuromuscular blocking trend curve exceeds a recovery threshold.

7. The method of claim 4 further comprising the step of displaying the predicted neuromuscular blocking trend curve.

8. The method of claim 4 wherein the displayed predicted neuromuscular blocking trend curve includes both measured and predicted TOF ratios.

9. The method of claim 1 further comprising the step of taking action to accelerate recovery time when the predicted recovery time exceeds a desired recovery time.

10. The method of claim 9 wherein the step of taking action includes delivering an antidote to the patient.

11. The method of claim 1 further comprising the step of outputting a notification instructing a user to initiate an extubation procedure at the estimate recovery time.

12. The method of claim 4 further comprising the steps of:

determining the TOF ratio at regular intervals after the second measurement time until the predicted recovery time;

comparing the determined TOF ratio to the TOF ratio of the predicted neuromuscular blocking trend curve for the measurement time; and

alerting a user when the determined TOF ratio differs from the predicted TOF ratio for the measurement time.

13. A method to estimate recovery time of a patient from neuromuscular block (NMB), comprising:

operating a stimulator to apply applying a first train-of-four (TOF) stimulation to a nerve of the patient at a first measurement time;

utilizing an electromyography (EMG) sensor to detect a first muscle twitch, a second muscle twitch, a third muscle twitch and a fourth muscle twitch in response to the first TOF stimulation;

calculating a first train-of-two (TO2) ratio based on the first muscle twitch and the second muscle twitch at the first measurement time; operating the stimulator to apply a second TOF stimulation to the nerve of a patient at a second measurement time;

utilizing the electromyography (EMG) sensor to detect a first muscle twitch, a second muscle twitch, a third muscle twitch and a fourth muscle twitch in response to the second TOF stimulation;

calculating a second TO2 ratio based on the first muscle twitch and the second muscle twitch at the second measurement time;

utilizing a controller configured to create a predicted neuromuscular blocking trend curve; and

utilizing a controller configured to predict the estimated recovery time based on the predicted neuromuscular blocking trend curve.

14. The method of claim 13 further comprising the step of displaying the predicted neuromuscular blocking trend curve on a display device.

15. The method of claim 14 wherein the displayed predicted neuromuscular blocking trend curve includes both measured and predicted TOF ratios.

16. The method of claim 13 further comprising the steps of:

calculating a first train-of-four (TOF) ratio based on the first muscle twitch and the fourth muscle twitch at the first measurement time;

calculating a second train-of-four (TOF) ratio based on the first muscle twitch and the fourth muscle twitch at the second measurement time;

applying the predicted slope to the calculated first and second TOF ratios to create the predicted neuromuscular blocking trend curve.

17. The method of claim 16 further comprising the steps of:

determining the TOF ratio at regular intervals after the second measurement time until the predicted recovery time at regular intervals;

comparing the determined TOF ratio to the TOF ratio of the predicted neuromuscular blocking trend curve for the measurement time; and

alerting a user when the determined TOF ratio differs from the predicted TOF ratio for the measurement time.

18. A medical device for monitoring depth of relaxation of a patient, comprising:

a stimulator configured to apply train-of-four (TOF) stimulation to a nerve of the patient at first and second measurement times;

an electromyography (EMG) sensor configured to detect a first muscle twitch, a second muscle twitch, a third muscle twitch and a fourth muscle twitch in response to the TOF stimulation at the first and second measurement times;

a controller configured to create a predicted neuromuscular blocking trend curve based on train-of-two (TO2) ratios calculated based on the detected first and second muscle twitches at the first and second measurement times, wherein the predicted neuromuscular blocking trend curve indicates a predicted extubation time.

19. The medical device of claim 18 further comprising a display for visually displaying the predicted neuromuscular blocking trend curve.

20. The medical device of claim 19 wherein the predicted neuromuscular blocking trend curve included measured TOF ratios and predicted TOF ratios.