Treatment of gliomas using organonitro compound combination therapy
The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.
1. A method of treating a glioma in a human, comprising the steps of:
(a) administering to the patient in need thereof a therapeutically effective amount of a formulation comprising temozolomide, and within about 2 days thereafter subjecting the glioma to radiation therapy; and
(b) administering to the patient at least one dose of a therapeutically effective amount of a formulation comprising ABDNAZ within about 7 days of administration of a first dose of the temozolomide; to treat the glioma.
2. The method of claim 1 , wherein the formulation comprising temozolomide is administered daily for at least 2 weeks.
3. A method of treating a glioma in a human, comprising the steps of:
(a) administering to the patient in need thereof a therapeutically effective amount of a formulation comprising irinotecan, and within about 7 days subjecting the glioma to radiation therapy; and
(b) administering to the patient at least one dose of a therapeutically effective amount of a formulation comprising ABDNAZ within about 7 days of administration of a first dose of the irinotecan; to treat the glioma.
4. The method of claim 3 , wherein the formulation comprising irinotecan is administered at least once per week for a duration of at least 2 weeks.
5. The method of claim 1 , wherein the human is an adult human.
6. The method of claim 1 , wherein the human is a pediatric human.
7. The method of claim 1 , wherein there is at least a 20% reduction in the size of at least one glioma tumor in the human.
8. The method of claim 1 , wherein there is at least a 20% reduction in the number of glioma tumors in the human.
9. The method of claim 3 , wherein the human is an adult human.
10. The method of claim 3 , wherein the human is a pediatric human.
11. The method of claim 3 , wherein there is at least 20% reduction in the size of at least one glioma tumor in the human.
12. The method of claim 3 , wherein there is at least a 20% reduction in the number of glioma tumors in the human.