All-natural enteric soft capsules
View Patent ↗Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the compositions and methods for manufacturing all-natural enteric soft capsules comprising Type A gelatin and matrix fills are described. In one embodiment, the enteric soft capsules comprise active ingredients such as non-steroidal anti-inflammatory drugs (NSAIDs). In another embodiment, the enteric soft capsule comprises matrix fills of omega-3 fatty acids.
1. A method for manufacturing an enteric soft capsule, the method comprising:
(a) combining 20% to 40% Type A gelatin by mass 2% to 7% pectin by mass, and 8% to 30% glycerol by mass with heating to form a gel mass with a viscosity of 20,000 cP to 30,000 cP;
(b) forming the enteric soft capsule from the gel mass using rotary die technology; and
(c) adding a fill comprising one or more active ingredients to the enteric soft capsule;
wherein the obtained enteric soft capsule consists of gelatin Type A, pectin, glycerol, and one or more active ingredients.
2. The enteric soft capsule formed by the method of claim 1 .
3. The capsule of claim 2 , wherein the capsule does not dissolve in simulated gastric fluid having a pH of 1.2 for at least 2 hours, and begins dissolution in simulated intestinal fluid having a pH of 6.8 within about 10 minutes.
4. The capsule of claim 2 , wherein the fill comprising one or more active ingredients comprises fish oil or a non-steroidal anti-inflammatory drug.
5. The capsule of claim 4 , wherein the fish oil comprises eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and one or more fat-soluble vitamins.
6. The capsule of claim 4 , wherein the non-steroidal anti-inflammatory drug comprises diclofenac.