IP Library Granted Patent US 11,026,956
Granted Patent B2
US 11,026,956 · App. 15/992,537 · Granted Jun 8, 2021

Cancer drug and uses

Inventors: Robin M. Bannister (Essex, GB); John Brew (Hertfordshire, GB); Gregory A. Stoloff (London, GB)
Assignee: Health Clinics Limited
A61K31/59A23L33/10A61K9/48A61K9/4858A61K31/05A61K31/155A61K31/19A61K31/225A61K31/352A61K31/353A61K31/357A61K31/366A61K31/375A61K31/40A61K31/4184A61K31/517A61K31/7068A61K39/39558Y02A50/30
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Quick Facts
Patent No.
US 11,026,956
App. No.
15/992,537
Granted
Jun 8, 2021
Kind
B2
Abstract

A pharmaceutical composition comprising a cancer therapeutic that is capable of inhibiting and/or reducing the ability of a cancer cell to take up and utilize glucose or other energy source, a lipid or other building block of a cell membrane or organelle, and/or cholesterol. The pharmaceutical composition can comprise one or more cancer therapeutics that can be administered individually or in combination to an individual.

Claims (21)

1. A pharmaceutical kit comprising an anti-diabetic drug, a statin, and a glycolysis inhibitor.

2. The pharmaceutical kit according to claim 1 , wherein the anti-diabetic drug is a biguanide, a thiazolidinedione, a secretagogue, an alpha-glucosidase inhibitor and/or a peptide analog, a cinnamon, a thiamine, or any combination thereof.

3. The pharmaceutical kit according to claim 2 , wherein the biguanide is a metformin, a phenformin, a buformin, or any combination thereof.

4. The pharmaceutical kit according to claim 1 , wherein the statin is an atorvastatin, a fluvastin, a lovastatin, a pitavastatin, a pravastatin, a rosuvastatin, a simvastatin, or any combination thereof.

5. The pharmaceutical kit according to claim 1 , wherein the glycolysis inhibitor is a hexokinase inhibitor, a phosphoglucose isomerase inhibitor, a fructosebisphosphate inhibitor, a triosephosphate isomerase inhibitor, a glyceraldehyde phosphate dehydrogenase inhibitor, a phosphoglycerate kinase inhibitor, a phosphoglycerate mutase inhibitor, an enolase inhibitor and/or a pyruvate kinase inhibitor, an anti-helminthic agent, an anti-malarial agent, an antibiotic, or any combination thereof.

6. The pharmaceutical kit according to claim 5 , comprising an anti-diabetic drug, a statin, an anti-helminthic agent, and an anti-malarial agent.

7. The pharmaceutical kit according to claim 6 , wherein the anti-diabetic drug is a biguanide, the anti-helminthic agent is a benzimidazole, and the anti-malarial agent is a doxycycline.

8. The pharmaceutical kit according to claim 7 , wherein the biguanide is a metformin, the statin is an atorvastatin, and the benzimidazole is a mebendazole.

9. The pharmaceutical kit according to claim 5 , wherein the anti-helminthic agent includes an abamectin, an aminoacetonitriles, a benzimidazole, a diethylcarbamazine, an ivermectin, a levamisole, niclosamide, an octadepsipeptides, a phosphoric acid, a praziquantel, a spiroindoles, a suramin, a pyrantel pamoate, or any combination thereof.

10. The pharmaceutical kit according to claim 9 , wherein the benzimidazole is an albendazole, a fenbendazole, a flubendazole, a thiabendazole, a triclabendazole, or any combination thereof.

11. The pharmaceutical kit according to claim 10 , wherein the flubendazole is a mebendazole.

12. The pharmaceutical kit according to claim 5 , wherein the anti-malarial agent includes an amodiaquine, an artemisinin, an atovaquone, a chloroquine, a clindamycin, a doxycycline, a halofantrine, a mefloquine, a primaquine, a proguanil, a pyrimethamine, a quinine, a rufigallol, a sulphonamide, or any combination thereof.

13. The pharmaceutical kit according to claim 12 , wherein the artemisinin is an arteether, an artelinate, an artelinic acid, an artemether, an artemotil, an artemisinin, an artenimol, an arterolane, an artesunate, a dihydroartemisinin, a dihydroartemisinin methyl ether, or any combination thereof.

14. The pharmaceutical kit according to claim 1 , further comprising a glucose intake inhibitor.

15. The pharmaceutical kit according to claim 14 , wherein the glucose intake inhibitor includes a GLUT-1 receptor inhibitor.

16. The pharmaceutical kit according to claim 15 , wherein the GLUT-1 receptor inhibitor is Vitamin C.

17. The pharmaceutical kit according to claim 1 , further comprising a lipid intake inhibitor.

18. The pharmaceutical kit according to claim 17 , wherein the lipid intake inhibitor includes an LDL receptor inhibitor, an SR-81 inhibitor, an SR-82 inhibitor, a SR-83/CD36 receptor inhibitor, or any combination thereof.

19. The pharmaceutical kit according to claim 18 , wherein the LDL receptor inhibitor is Vitamin D.

20. The pharmaceutical kit comprising a biguanide, a statin, a benzimidazole, and a cytotoxic antibiotic.

21. The pharmaceutical kit comprising a metformin, an atorvastatin, a mebendazole, and a doxycycline.

Assignments (6)
LIEN Recorded Sep 12, 2024
From: STAGEZERO LIFE SCIENCES LTD.
To: SUNSTEIN LLP
Reel/Frame 068571/0041 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 10, 2021
From: STOLOFF, GREGORY A.
To: HEALTH CLINICS LIMITED
Reel/Frame 058357/0615 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 10, 2021
From: HEALTH CLINICS LIMITED
To: CLINICS OPERATIONS LIMITED
Reel/Frame 058358/0588 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 1, 2019
From: BREW, JOHN; BANNISTER, ROBIN M.
To: BIOCOPEA LIMITED
Reel/Frame 047877/0990 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 1, 2019
From: BREW, JOHN; BANNISTER, ROBIN M.
To: BIOCOPEA LIMITED
Reel/Frame 047877/0994 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 1, 2019
From: BIOCOPEA LIMITED
To: HEALTH CLINICS LIMITED
Reel/Frame 047878/0001 →
Continuity (6)
Continuation 15451346 · Mar 6, 2017
Continuation 14155320 · Jan 14, 2014
Provisional Application 61872822 · Sep 2, 2013
Provisional Application 61782585 · Mar 14, 2013
Provisional Application 61752360 · Jan 14, 2013
Related Publication 20180271883A1 · Sep 27, 2018
Cited By (1)
US 12,544,336