COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.
1 . A compound of Formula I:
or a pharmaceutically acceptable salt thereof,
wherein:
Y is independently selected from NH and CH 2 ;
X is independently selected from acylhydrazone, ester, amide or CH 2
n and m are independently selected from 0, 1, 2, 3, 4, 5, and 6;
R 1 and R 2 each is Cl, or
R 1 and R 2 are joined to form an oxalate;
R 3 and R 4 each is NH 3 , or
R 3 and R 4 are joined together to form cyclohexane-1,2-diamine and
R 5 is alkyl or
2 . The compound of claim 1 , wherein the compound has Formula Ia:
3 . The compound of claim 1 , wherein R 1 and R 2 each is Cl.
4 . The compound of claim 1 , wherein Y is CH 2 , X is CH 2 , n is 0 and m is 3.
5 . The compound of claim 1 , wherein Y is NH, X is CH 2 , n is 0 and m is 4.
6 . The compound of claim 1 , wherein the compound is not
7 . The compound of claim 1 , wherein R 3 is alkyl.
8 . The compound of claim 7 , wherein R 3 is methyl.
9 . The compound of claim 1 , wherein R 3 is
10 . A compound selected from:
11 . A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
12 . A method of treating cancer selected from lung cancer, breast cancer, colorectal cancer, ovarian cancer, bladder cancer, prostate cancer, cervical cancer, renal cancer, leukemia, central nervous system cancers, myeloma, and melanoma, comprising administering a therapeutically effective amount of a compound of claim 1 .
13 . A method of treating cancer selected from lung cancer, breast cancer, colorectal cancer, ovarian cancer, bladder cancer, prostate cancer, cervical cancer, renal cancer, leukemia, central nervous system cancers, myeloma, and melanoma, comprising administering a therapeutically effective amount of a composition of claim 11 .
14 . A method of inhibiting proliferation of a cell comprising contacting the cell with an effective amount of a compound of claim 1 .
15 . The method of claim 14 , wherein the cell is a cancer cell.