Compositions for preventing and/or treating degenerative disorders of the central nervous system
View Patent ↗The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the central nervous system. In particular, the present invention provides methods for preventing and/or treating Parkinson's disease.
1. A compound of Formula III:
wherein:
R 1 is C(R 2 )(R 3 )(R 4 );
R 2 is hydrogen, —OH or halogen;
R 3 is hydrogen, —OH, halogen or CH 3 ;
R 4 is halogen, CH 3 , phenyl, fluorophenyl, methylphenyl, or cyclohexylmethyl, wherein when R 4 is a halogen both R 2 and R 3 cannot be hydrogen;
R 3 and R 4 may join with the carbon to which they are attached to form a cycloalkyl ring, which may be optionally substituted with one or more halogen atoms;
R 7 is —OH or halogen; and
R 8 is hydrogen, halogen or —CH 3 ,
provided that R 2 and R 3 cannot both be hydrogen when R 4 is a halogen or phenyl, R 7 is —OH and R 8 is hydrogen,
or a pharmaceutically acceptable salt or solvate thereof.
2. The compound of claim 1 , wherein R 3 and R 4 are joined with the carbon to which they are attached to form a cycloalkyl ring, and the cycloalkyl ring is substituted with one or more fluorine atoms.
3. The compound of claim 1 , wherein R 4 is halogen, phenyl, fluorophenyl, methylphenyl, or cyclohexylmethyl.
4. The compound of claim 1 , wherein R 4 is halogen, fluorophenyl, methylphenyl, or cyclohexylmethyl.
5. The compound of claim 1 , wherein:
R 2 is hydrogen or halogen;
R 3 is hydrogen, —OH, or halogen;
R 4 is halogen, CH 3 , phenyl, fluorophenyl, methylphenyl, or cyclohexylmethyl;
R 7 is —OH; and
R 8 is hydrogen.
6. The compound of claim 1 , wherein:
R 2 is hydrogen or halogen;
R 3 is hydrogen, —OH, or halogen;
R 4 is halogen, CH 3 , or phenyl;
R 7 is —OH; and
R 8 is hydrogen.
7. The compound of claim 1 , wherein:
R 2 is hydrogen or halogen;
R 3 is —OH or halogen;
R 4 is halogen, CH 3 , or phenyl;
R 7 is —OH; and
R 8 is hydrogen.
8. The compound of claim 1 , wherein:
R 2 is hydrogen;
R 3 is —OH or halogen;
R 4 is halogen, CH 3 , or phenyl;
R 7 is —OH; and
R 8 is hydrogen.
9. The compound of claim 1 , wherein:
R 2 is hydrogen or fluorine;
R 3 is fluorine;
R 4 is fluorine, CH 3 , or phenyl;
R 7 is —OH; and
R 8 is hydrogen.
10. A pharmaceutical composition comprising a compound of claim 1 and at least one pharmaceutically acceptable carrier.