Oil foamable carriers and formulations
A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
1. An essentially waterless foam composition comprising:
(a) a liquid oil;
(b) a modulating agent;
(c) a foam stabilizing agent comprising at least two surface-active agents;
(d) an emollient comprising a solid wax and/or solid oil; and
(e) a silicone;
wherein the surface-active agents are not sorbitan fatty acid esters;
wherein the composition does not contain a polymeric agent; and
wherein the foam does not comprise a pharmaceutical or cosmetic active agent.
2. The foam composition of claim 1 , wherein the liquid oil is about 60% to about 95% by weight of the composition.
3. The foam composition of claim 1 , wherein the liquid oil is selected from the group consisting of a mineral oil, a MCT oil, a liquid paraffin, a vegetable oil, an essential oil, an organic oil, a lipid, or a mixture of two or more thereof.
4. The foam composition of claim 1 , wherein the liquid oil is a mixture of heavy mineral oil and light mineral oil having a weight ratio from about 1:5 to about 25:1.
5. The foam composition of claim 1 , wherein the amount of the at least two surface-active agents is between about 0.2% and about 8% by weight of the composition.
6. The foam composition of claim 1 , wherein the at least two surface-active agents comprise between about 1% and about 6% by weight of the composition.
7. The foam composition of claim 1 , wherein the modulating agent is between about 0.1% to about 10% by weight of the composition.
8. The foam composition of claim 1 , wherein the modulating agent is between about 1% to about 5% by weight of the composition.
9. The foam composition of claim 1 , wherein at least one of the surface-active agents comprises a fatty acid ester.
10. The foam composition of claim 9 , wherein the fatty acid ester is selected from the group consisting of a monoglyceride, diglyceride, or triglyceride, or a mixture of any two or more thereof, wherein the side chain of the monoglyceride, diglyceride, or triglyceride is a saturated hydrocarbon.
11. The foam composition of claim 9 , wherein the fatty acid ester comprises glyceryl monostearate.
12. The foam composition of claim 1 , wherein the solid wax or solid oil comprises a solid paraffin, a hydrogenated oil, a hydrogenated emollient, palmitic acid, or a mixture of any two or more thereof.
13. The foam composition of claim 1 , wherein the emollient comprises a solid wax and a solid oil.
14. The foam composition of claim 13 , wherein the emollient further comprises a cocoglyceride, PPG 15 stearyl alcohol, octyldodecanol, isopropyl myristate, diisopropyl adipate, cetearyl octanoate isohexadecanol, diisopropyl adipate, or a mixture of any two or more thereof.