Tissue modification devices and methods of using the same
Tissue modification devices are provided. Aspects of the devices include an elongated member having a proximal end and a distal end. The distal end of the elongated member is dimensioned to pass through a minimally invasive body opening and includes a distal end integrated visualization sensor and tissue modifier. In some instances, the devices further include an integrated articulation mechanism that imparts steerabilily to at least one of the visualization sensor, the tissue modifier and the distal end of the elongated member. Also provided are methods of modifying internal target tissue of a subject using the tissue modification devices.
1. A tissue modification device, comprising:
a rigid elongated member comprising a proximal end and a distal end, the distal end dimensioned to be passed through a minimally invasive body opening;
a radiofrequency electrode positioned on the rigid elongated member, the radiofrequency electrode configured to deliver radiofrequency energy to a tissue, the radiofrequency energy comprising a frequency;
a mechanical actuator, the mechanical actuator configured to extend the radiofrequency electrode beyond the distal end of the rigid elongated member at a linear translation frequency; and
a controller configured to synchronize the linear translation frequency to operate in a coordinated manner with the radiofrequency energy frequency such that the radiofrequency electrode is configured to deliver radiofrequency energy only while at a position other than when the radiofrequency electrode is at a fully extend oscillation position.
2. The device of claim 1 , wherein the linear translation frequency is configured such that the device provides variable tactile feedback to an operator depending upon a type of tissue in contact with the radiofrequency electrode.
3. The device of claim 1 , wherein the radiofrequency electrode is configured to stop delivery of radiofrequency energy when the radiofrequency electrode reaches the fully extend oscillation position.
4. The device of claim 3 , wherein the linear translation frequency is configured such that radiofrequency energy is preferentially delivered to soft tissue.
5. The device of claim 1 , wherein the electrode is configured to deflect at an angle from a longitudinal axis passing through the elongated member.
6. The device of claim 1 , wherein the electrode is configured to translate in both a distal direction away from the center of the elongated member and a proximal direction toward the center of the elongated member.
7. The device of claim 1 , wherein the mechanical actuator is selected from the group of a voice coil motor, a solenoid, and a pneumatic actuator.
8. The device of claim 1 , wherein the linear translation frequency is 50 Hz or greater.
9. The device of claim 1 , wherein the radiofrequency energy frequency is equal to the linear translation frequency.
10. The device of claim 1 , wherein the radiofrequency energy further comprises a waveform, the waveform phase-shifted relative to a linear translation waveform of the linear actuator.
11. The device of claim 1 , further comprising a sensor positioned at the distal end of the elongated member, the sensor configured to collect data on the linear translation of the radiofrequency electrode.
12. The device of claim 11 , wherein the sensor comprises an accelerometer.
13. The device of claim 11 , wherein the sensor comprises an optical encoder.
14. The device of claim 1 , wherein the radiofrequency electrode is circular.
15. The device of claim 1 , further comprising a visualization sensor positioned at the distal end of the elongated member.
16. The device of claim 1 , further comprising a physiological sensor configured to collect physiological data.
17. The device of claim 16 , wherein a controller is configured to transmit the physiological data to an image display component, wherein the image display component is configured to provide the physiological data to a user.
18. The device of claim 1 , wherein the device further comprises an integrated articulation mechanism that imparts steerability to the distal end of the elongated member.
19. The device of claim 18 , wherein the distal end of the elongated member is rotatable about its longitudinal axis.