IP Library Granted Patent US 10,778,167
Granted Patent B2
US 10,778,167 · App. 16/001,780 · Granted Sep 15, 2020

Femtowatt non-vacuum tube detector assembly

Inventors: Karan Mohan (Union City, CA); Marcelo Martinez (Davis, CA)
Assignee: Labrador Diagnostics LLC
H03G3/001G01N15/1434H01L31/02019H03F3/08H03F3/45071H03M1/0607G01N21/645G01N2015/0693G01N2015/1006
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,778,167
App. No.
16/001,780
Granted
Sep 15, 2020
Kind
B2
Abstract

In one embodiment, a femtowatt sensitivity optical detector is provided using one or more photodiodes, intended as a replacement for the photomultiplier based photon counting unit.

Claims (23)

1. A device comprising:

a plurality of photodiodes;

an analog amplification system comprising at least a high gain transimpedance amplifier (TIA) and at least a buffer on each of said photodiodes, followed by a fully differential amplifier to combine outputs of multiple TIAs; and

a digital acquisition system comprising at least one analog-to-digital converter (ADC), followed by a programmable processor, which is linked to a central processor as well as on-board memory, wherein the programmable processor implements a data acquisition algorithm, wherein the programmable processor implements the data acquisition algorithm using a long time average;

wherein the device detects signals at femtowatt sensitivity.

2. The device of claim 1 further comprising a mechanical housing module of the analog amplification system are contained.

3. The device of claim 1 further comprising at least one shaped reflector to direct light to at least one of said photodetectors.

4. The device of claim 3 wherein the shaped reflector has a semi-hemispherical shape.

5. The device of claim 3 wherein the shaped reflector comprises at least one opening sized and positioned to allow a sample vessel to be placed at a desired location in a cavity defined at least in part by the shaped reflector.

6. A device comprising:

a plurality of photodiodes;

an analog amplification system comprising at least a high gain transimpedance amplifier (TIA) and at least a buffer on each of said photodiodes, followed by a fully differential amplifier to combine outputs of multiple TIAs;

a digital acquisition system comprising at least one analog-to-digital converter (ADC), followed by a programmable processor, which is linked to a central processor as well as on-board memory,

wherein the programmable processor implements a data acquisition algorithm, wherein the programmable processor implements the data acquisition algorithm using a long time average;

wherein the device detects signals at femtowatt sensitivity; and

a plurality of digital-to-analog converters (DACs) on the programmable processor configured to provide feedback control.

7. A device comprising:

a plurality of photodiodes;

an analog amplification system comprising at least a high gain transimpedance amplifier (TIA) and at least a buffer on each of said photodiodes, followed by a fully differential amplifier to combine outputs of multiple TIAs;

a digital acquisition system comprising at least one analog-to-digital converter (ADC), followed by a programmable processor, which is linked to a central processor as well as on-board memory,

wherein the programmable processor implements a data acquisition algorithm, wherein the programmable processor implements the data acquisition algorithm using a long time average;

wherein the device detects signals at femtowatt sensitivity; and

a plurality of digital-to-analog converters (DACs) on the programmable processor configured to provide feedback control, wherein one of said DACs is configured for offset adjustment in the differential amplifier, and one of said DACs is set the reference level of the ADC.

Assignments (3)
CHANGE OF NAME Recorded Apr 15, 2020
From: THERANOS IP COMPANY, LLC
To: LABRADOR DIAGNOSTICS LLC
Reel/Frame 052410/0432 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 13, 2020
From: THERANOS, INC.
To: THERANOS IP COMPANY, LLC
Reel/Frame 052385/0844 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2020
From: MOHAN, KARAN; MARTINEZ, MARCELO
To: THERANOS, INC.
Reel/Frame 052354/0419 →
Continuity (5)
Continuation 15299077 · Oct 20, 2016
Continuation 14849264 · Sep 9, 2015
Continuation PCTUS2014030823 · Mar 17, 2014
Provisional Application 61801996 · Mar 15, 2013
Related Publication 20190081603A1 · Mar 14, 2019