Intraocular lens compositions
The present invention provides novel intraocular lens compositions comprising a hydroxyl functional acrylic monomer and have a high Abbe number, minimal glistenings, and suitable mechanical properties for small incision delivery.
1. A copolymeric material for use in an intraocular lens, wherein the copolymeric material is formed by polymerizing a composition comprising 80-99 weight % of one or more monomers of Formula I:
wherein R, R′, and R″ are selected from the group consisting of hydroxyl, R 3 , and R 4 , and provided that R, R′, and R″ are all different; R is R 3 , R′ is hydroxyl, R″ is R 4 , X is O, R 1 is H, and R 2 is selected from the group consisting of norbonanemethyl, cyclohexylmethyl, and cyclohexylethyl.
2. The copolymeric material of claim 1 , wherein R 2 is norbonanemethyl.
3. The copolymeric material of claim 1 , wherein R 2 is cyclohexylmethyl.
4. The copolymeric material of claim 1 , wherein R 1 is H and R 2 is cyclohexylethyl.
5. The copolymeric material of claim 1 , further comprising a cross-linking agent.
6. The copolymeric material of claim 1 wherein the copolymeric material has a refractive index when measured hydrated at 35° C. of 1.45-1.52.
7. The copolymeric material of claim 6 , wherein the copolymeric material has a refractive index when measured hydrated at 35° C. of 1.47-1.52.
8. The copolymeric material of claim 1 , wherein the copolymeric material has an Abbe number ≥45.
9. The copolymeric material of claim 8 , wherein the copolymeric material has an Abbe number ≥50.
10. A copolymeric material for use in an intraocular lens, wherein the copolymeric material is formed by polymerizing a composition comprising 50-95 weight % of one or more monomers of Formula I and a hydrophilic acrylic monomer:
wherein R, R′, and R″ are selected from the group consisting of hydroxyl, R 3 , and R 4 , and provided that R, R′, and R″ are all different; X is selected from the group consisting of 0, C and S; R 1 is selected from the group consisting of H and C 1 -C 3 alkyl; and R 2 is a saturated C 5 -C 12 alkyl.
11. The copolymeric material of claim 10 , wherein R is R 3 ; R′ is hydroxyl; R″ is R 4 ; X is O; R 1 is H or CH 3 ; and R 2 is a saturated C 6 -C 8 alkyl.
12. The copolymeric material of claim 11 , wherein R 1 is H and R 2 is norbonanemethyl.
13. The copolymeric material of claim 11 , wherein R 1 is H and R 2 is cyclohexylmethyl.
14. The copolymeric material of claim 11 , wherein R 1 is H and R 2 is cyclohexyl.
15. The copolymeric material of claim 11 , wherein R 1 is H and R 2 is cyclohexylethyl.
16. The copolymeric material of claim 10 , wherein the hydrophilic acrylic monomer is selected from the group consisting of: 2-hydroxyethyl methacrylate; 2-hydroxyethyl acrylate; and N,N-dimethylacrylamide.
17. The copolymeric material of claim 10 wherein the copolymeric material has a refractive index when measured hydrated at 35° C. of 1.45-1.52.
18. The copolymeric material of claim 17 , wherein the copolymeric material has a refractive index when measured hydrated at 35° C. of 1.47-1.52.
19. The copolymeric material of claim 10 , wherein the copolymeric material has an Abbe number ≥45.
20. The copolymeric material of claim 19 , wherein the copolymeric material has an Abbe number ≥50.