CD38 antibody drug conjugate
There is disclosed an antibody drug conjugate (ADC) having an IgG antibody that binds to a CD38 target conjugated at a Cys site in the hinge region of an IgG antibody. There is further disclosed a method for treating multiple myeloma comprising providing an effective amount of a CD38 ADC.
1. An antibody drug conjugate (ADC) composition comprising an IgG antibody that binds to CD38, a linker moiety conjugated to a Cys residue in a hinge region of an IgG antibody, wherein the IgG antibody comprises a heavy chain mutated such that the hinge region contains only one Cys residue, wherein the ADC is chosen from
2. The ADC composition of claim 1 , wherein the ADC is
3. The ADC composition of claim 1 , wherein the ADC is
4. The ADC composition of claim 1 , wherein the ADC is
5. The ADC composition of claim 1 , wherein the ADC is
6. The ADC composition of claim 1 , wherein the ADC is
7. The ADC composition of claim 1 , wherein the ADC is
8. An anti-CD38 ADC composition comprising:
(a) an anti-CD38 IgG antibody comprising a heavy chain variable region comprising the sequence of SEQ ID NO. 1 and a light chain variable region comprising the sequence of SEQ ID NO. 2 or 3;
(b) a conjugation linker moiety, wherein the conjugation linker comprises a linker and a conjugation moiety which covalently binds to a single Cys residue in a hinge region of an IgG antibody, and
wherein the anti-CD38 ADC is chosen from:
wherein Ab is the anti-CD38 IgG antibody.
9. The ADC composition of claim 8 , wherein the ADC is
10. The ADC composition of claim 8 , wherein the ADC is
11. The ADC composition of claim 8 , wherein the ADC is
12. The ADC composition of claim 8 , wherein the ADC is
13. The ADC composition of claim 8 , wherein the ADC is
14. The ADC composition of claim 8 , wherein the ADC is
15. The ADC composition of claim 8 , wherein the heavy chain hinge region of the IgG antibody is mutated such that the heavy chain hinge region contains only one Cys residue.
16. A compound selected from:
or a pharmaceutically acceptable salt thereof.