Markovnikov-selective palladium catalyst for carbonylation of alkynes with heteroarenes
Markovnikov-selective palladium catalyst for carbonylation of alkynes is formed from a bisphosphite having formula (1): The carbonylation catalyst is suited for the preparation of a branched heteroarene-keto product from an alkyne substrate, CO and heterocycle in high yields with low amounts of the linear product.
1. Compound having the structure (1):
2. A process for Markovnikov-selective carbonylation of an alkyne in whose molecule there is one hydrogen atom bonded to a triply bonded carbon atom to form a heteroarene-keto product comprising the following process steps to form a reaction mixture:
a) initially charging the alkyne,
b) adding a compound according to claim 1 and a substance including Pd,
c) feeding N-methylpyrrole and CO,
d) heating the reaction mixture to react the alkyne with CO and N-methylpyrrole to form the heteroarene-keto product.