Compounds and uses thereof

1. A compound of Formula (I):

or a pharmaceutically acceptable salt thereof;

wherein:

X is a bond, —C(═O)—, —S(═O)—, or —S(═O) 2 —;

Y is a bond, —C(═O)—, —S(═O)—, or —S(═O) 2 —;

Ring A is substituted or unsubstituted, 4-membered, monocyclic heterocyclyl, substituted or unsubstituted, 7-membered, monocyclic heterocyclyl, or substituted or unsubstituted, 7- to 10-membered, spiro bicyclic heterocyclyl, wherein one or two atoms in the heterocyclic ring are independently selected from the group consisting of oxygen and nitrogen;

Ring Y is substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

each instance of R A is independently hydrogen, halogen, substituted or unsubstituted alkyl, —OR A1 , —N(RA A1 ) 2 , oxo, or a nitrogen protecting group when attached to a nitrogen atom;

each instance of RA A1 is independently hydrogen, substituted or unsubstituted alkyl, a nitrogen protecting group when attached to a nitrogen atom, or an oxygen protecting group when attached to an oxygen atom, or two instances of RA A1 are joined to form substituted or unsubstituted heterocyclyl;

a is 0, 1, 2, or 3;

R B is substituted or unsubstituted alkyl or of the formula:

Ring B is substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

each instance of RB B1 is independently hydrogen, halogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —OR B1a , —N(R B1a ) 2 , —SR B1a , —CN, —SCN, —C(═NR B1a )R B1a , —C(═NR B1a )OR B1a , —C(═NR B1a )N(R B1a ) 2, —C(═O)R B1a , —C(═O)OR B1a , —C(═O)N(R B1a) 2 , —NO 2 , —NR B1a C(═O)R B1a , —NR B1a C(═O)OR B1a , —NR B1a C(═O)N(R B1a ) 2 , —OC(═O)R B1a , —OC(═O)OR B1a , —OC(═O)N(R B1a ) 2 , or a nitrogen protecting group when attached to a nitrogen atom, or two instances of R B1 are joined to form substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

each instance of R B1a is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of R B1a are joined to form substituted or unsubstituted heterocyclyl;

b is 0, 1, 2, 3, 4, or 5;

R C is hydrogen, substituted or unsubstituted C 1-6 alkyl, or a nitrogen protecting group;

R D is hydrogen, substituted or unsubstituted C 1-6 alkyl, or a nitrogen protecting group;

each instance of R L is independently hydrogen, halogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —OR L1 , —N(R L1 ) 2 , —SR L1 , —CN, —SCN, —C(═NR L1 )R L1 , —C(═NR L1 )OR L1 , —C(═NR L1 )N(R L1 ) 2 , —C(═O)R L1 , —C(═O)OR L1 , —C(═O)N(R L1 ) 2 , —NO 2 , —NR L1 C(═O)R L1 , —NR L1 C(═O)OR L1 , —NR L1 C(═O)N(R L1 ) 2 , —OC(═O)R L1 , —OC(═O)OR L1 , or —OC(═O)N(R L1 ) 2 , or two instances of RL are joined to form substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

each instance of R L1 is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of R L1 are joined to form substituted or unsubstituted heterocyclyl;

l is 0, 1, 2, 3, or 4; and

m is 0, 1, 2, 3, 4, or 5.

2. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

8. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

9. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

10. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

11. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

12. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

13. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

14. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

15. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

16. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

17. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

18. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

19. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

20. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

21. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

22. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

23. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

24. The compound of claim 1 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

25. A pharmaceutical composition comprising the compound of claim 1 , and optionally a pharmaceutically acceptable excipient.

26. The pharmaceutical composition of claim 25 , wherein the pharmaceutical composition is suitable for topical administration to the eye of a subject.

27. A method of treating an ocular disease in a subject in need thereof comprising: administering to the subject a therapeutically effective amount of the compound of claim 1 .

28. The method of claim 27 , wherein the subject is a human.

29. The method of claim 27 , wherein the ocular disease is macular degeneration, diabetic retinopathy, retinoblastoma, edema, diabetic macular edema or retinal vein occlusion.

30. The method of claim 27 , wherein the ocular disease is age-related macular degeneration.

31. The method of claim 27 , wherein the ocular disease is corneal neovascularization.

32. The method of 27 , wherein the compound is administered to an eye of the subject.

33. The method of 27 , wherein the compound is administered topically to an eye of the subject.

34. A method of inhibiting growth factor signaling in a subject in need thereof comprising:

administering to the subject a therapeutically effective amount of the compound of claim 1 .

35. A method of inhibiting growth factor signaling in a cell comprising:

contacting the cell with an effective amount of the compound of claim 1 .

36. The method of claim 34 , wherein the cell is in vitro.

37. A kit comprising:

the compound of claim 1 ; and

instructions for using the kit.

38. The compound of claim 1 , wherein the compound is,

or a pharmaceutically acceptable salt thereof.

39. The compound of claim 1 , wherein:

each one of R C and R D is hydrogen or unsubstituted C 1-6 alkyl; and

each of R L is halogen or unsubstituted C 1-6 alkyl.

40. The compound of claim 39 , wherein:

each R A1 is independently hydrogen or substituted or unsubstituted alkyl; and

each R B1 is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroaryl, —OR B1a , or —N(R B1a ) 2 or two instances of R B1 are joined to form substituted or unsubstituted heterocyclyl; and

each R B1a is independently hydrogen or unsubstituted C 1-6 alkyl.

41. The compound of claim 40 , wherein:

each R A1 is independently hydrogen, unsubstituted C 1-6 alkyl, —CH 2 F, —CHF 2 , or —CF 3 ; and each R B1 is independently hydrogen, halogen, unsubstituted C 1-6 alkyl, —CH 2 F, —CHF 2 , or —CF 3 .

42. The compound of claim 39 , wherein:

each R A1 is independently hydrogen, unsubstituted C 1-6 alkyl, —CH 2 F, —CHF 2 , —CF 3 , —(CH 2 ) 2 Ph, or Bn.

43. The compound of claim 42 , wherein R B is

44. The compound of claim 42 , wherein each R B1 is independently hydrogen, halogen, unsubstituted C 1-6 alkyl, —CH 2 F, —CHF 2 , —CF 3 , —CH 2 —N(R B1a ) 2 , —CH 2 —N(unsubstituted C 1-6 alkyl)—(CH 2 ) 2-4 —OH,

—CH 2 —NH(R B1a ), Bn, —(CH 2 ) 2 Ph,

—OR B1a , —OPh, —OBn, —O(CH 2 ) 2 Ph, —O—CF 3 , —O—(CH 2 ) 2-4 —N(R B1a ) 2 , —O—(CH 2 )—N(unsubstituted C 1-6 alkyl) 2 , —O—(CH 2 ) 2 —N(CH 3 ) 2 , —O—(CH 2 ) 3 —N(CH 3 ) 2 ,

—N(R B1a ) 2 , or —CN, wherein each R B1a is independently hydrogen or unsubstituted C 1-6 alkyl.

45. the compound of claim 44 , wherein each RB B1 is, independently, —CH 2 —N(CH 3 )—(CH 2 ) 2 —OH, —CH 2 —NH(unsubstituted C 1-6 alkyl),

or —O—(CH 2 ) 2-4 —N(unsubstituted C 1-6 alkyl) 2 , or

46. The compound of claim 45 , wherein each R B1 is, independently, —O—(CH 2 ) 2 —N(CH 3 ) 2 , or —O—(CH 2 ) 3 —N(CH 3 ) 2 .