Sustained-release buprenorphine solutions
View Patent ↗The disclosure provides extended release pharmaceutical formulations comprising an opioid, particularly buprenorphine, a biocompatible organic solvent, and, optionally, a glycol, for use in the treatment of pain or opioid dependence. The pharmaceutical formulations are in the form of a pharmaceutical solution.
1. An injectable pharmaceutical solution comprising about 10 wt % to about 45 wt % of buprenorphine free base and a solvent mixture; wherein the solvent mixture comprises N-methyl-2-pyrrolidone and about 10 wt % to about 70 wt % polyethylene glycol.
2. The solution of claim 1 , comprising about 15 wt % to about 35 wt % of buprenorphine free base.
3. The solution of claim 2 , comprising about 20 wt % of buprenorphine free base.
4. The solution of claim 2 , comprising about 30 wt % of buprenorphine free base.
5. The solution of claim 1 , wherein the solvent mixture comprises about 50 wt % to about 85 wt % of N-methyl-2-pyrrolidone and about 15 wt % to about 50 wt % of polyethylene glycol.
6. The solution of claim 5 , wherein the solvent mixture comprises about 50 wt % to about 80 wt % of N-methyl-2-pyrrolidone and about 20 wt % to about 50 wt % of polyethylene glycol.
7. The solution of claim 6 , wherein the solvent mixture comprises about 50 wt % to about 70 wt % of N-methyl-2-pyrrolidone and about 30 wt % to about 50 wt % of polyethylene glycol.
8. The solution of claim 6 , wherein the solvent mixture comprises about 60 wt % to about 80 wt % of N-methyl-2-pyrrolidone and about 20 wt % to about 40 wt % of polyethylene glycol.
9. The solution of claim 8 , wherein the solvent mixture comprises about 70 wt % to about 80 wt % of N-methyl-2-pyrrolidone and about 20 wt % to about 30 wt % of polyethylene glycol.
10. The solution of claim 1 , wherein the polyethylene glycol has an average molecular weight from about 100 to about 1,000.
11. The solution of claim 10 , wherein the polyethylene glycol has an average molecular weight of about 300.
12. The solution of claim 1 , comprising about 20 wt % of buprenorphine free base; wherein the weight ratio of N-methyl-2-pyrrolidone to polyethylene glycol is about 60:40.
13. A method of treating opioid dependence in a patient in need thereof, the method comprising subcutaneously injecting the patient with a therapeutically effective amount of the solution of claim 1 to treat the opioid dependence.
14. The method of claim 13 , comprising subcutaneously injecting the patient about once per month to about once every three months with the therapeutically effective amount of the solution.
15. An injectable pharmaceutical solution comprising about 20 wt % of buprenorphine free base and a solvent mixture; wherein the solvent mixture comprises N-methyl-2-pyrrolidone and polyethylene glycol in a weight ratio of about 60:40; and wherein the polyethylene glycol has an average molecular weight of about 300.
16. A method of treating opioid dependence in a patient in need thereof, the method comprising subcutaneously injecting the patient with a therapeutically effective amount of the solution of claim 15 to treat the opioid dependence.
17. An injectable pharmaceutical solution comprising about 30 wt % of buprenorphine free base and a solvent mixture; wherein the solvent mixture comprises about 70 wt % to about 80 wt % of N-methyl-2-pyrrolidone and about 20 wt % to about 30 wt % of polyethylene glycol; and wherein the polyethylene glycol has an average molecular weight of about 300.
18. The solution of claim 17 , wherein the solvent mixture comprises about 75 wt % of N-methyl-2-pyrrolidone and about 25 wt % of polyethylene glycol.
19. A method of treating opioid dependence in a patient in need thereof, the method comprising subcutaneously injecting the patient with a therapeutically effective amount of the solution of claim 17 to treat the opioid dependence.
20. An injectable pharmaceutical solution comprising about 20 wt % of buprenorphine free base and a solvent mixture; wherein the solvent mixture comprises about 70 wt % to about 80 wt % of N-methyl-2-pyrrolidone and about 20 wt % to about 30 wt % of polyethylene glycol; and wherein the polyethylene glycol has an average molecular weight of about 300.
21. The solution of claim 20 , wherein the solvent mixture comprises about 75 wt % of N-methyl-2-pyrrolidone and about 25 wt % of polyethylene glycol.
22. A method of treating opioid dependence in a patient in need thereof, the method comprising subcutaneously injecting the patient with a therapeutically effective amount of the solution of claim 20 to treat the opioid dependence.